About the Authors

Steven D. Sheridan

Contributed equally to this work with: Steven D. Sheridan, Kraig M. Theriault

Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Kraig M. Theriault

Contributed equally to this work with: Steven D. Sheridan, Kraig M. Theriault

Affiliation Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Surya A. Reis

Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Fen Zhou

Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Jon M. Madison

Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Laurence Daheron

Affiliations Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America, Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Jeanne F. Loring

Affiliation Center for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America

Stephen J. Haggarty

haggarty@chgr.mgh.harvard.edu

Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Stanley Center for Psychiatric Research, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SS KT SR SH. Performed the experiments: SS KT FZ. Analyzed the data: SS KT SH SR JL. Contributed reagents/materials/analysis tools: SS KT FZ JM SH. Wrote the paper: SS KT JL SH. Coordinated the study: SS. Performed iPSC characterization, neural differentiation and phenotypic characterization: SS. Performed iPSC characterization, neural differentiation and phenotypic characterization, performed iPSC characterization, FMR1 promoter methylation and expression analysis, FMRP western analysis: KT. Derived a control iPSC line used in the study and contributed advice on characterizing differentiated neurons: FZ JM. Contributed unpublished data on other FXS iPSC lines: JL. Provided technical guidance, training and reagents for iPSC derivation: LD. Contributed financial support: SH.