About the Authors

Simon M. Agwale

sagwale@innovativebiotechng.com

Affiliations Clinical Virology Laboratory, Innovative Biotech, Keffi/Abuja, Nigeria, Frederick Innovative Technology Center, Innovative Biotech, Frederick, Maryland, United States of America

Joseph C. Forbi

Affiliations Clinical Virology Laboratory, Innovative Biotech, Keffi/Abuja, Nigeria, Frederick Innovative Technology Center, Innovative Biotech, Frederick, Maryland, United States of America

Frank Notka

Affiliation GeneArt AG, Regensburg, Germany

Terri Wrin

Affiliation Monogram Biosciences Inc., South San Francisco, California, United States of America

Jens Wild

Affiliation Molecular Microbiology and Gene Therapy Unit, Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany

Ralf Wagner

Affiliations GeneArt AG, Regensburg, Germany, Molecular Microbiology and Gene Therapy Unit, Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany

Hans Wolf

Affiliation Molecular Microbiology and Gene Therapy Unit, Institute for Medical Microbiology and Hygiene, University of Regensburg, Regensburg, Germany

Competing Interests

The authors declare competing financial interests: Geneart performed the gene design, optimization and synthesis. The authors also declare competing interests in the form of patent family WO04059556 including all national patents and pending applications. The authors declare that all other data and materials described in the manuscript adhere to all the PLoS ONE policies on sharing data and materials. FN and RW are employed by Geneart AG, which is a fully owned subsidiary of LifeTechnologies Corp.; JW and RW are employed by the University of Regensburg; HW is an emeritus professor. TW is the associate director of Virology (Research and Development), Monogram Biosciences Inc., USA. JCF and SMA are senior virologists/vaccinologists at Innovative Biotech. SMA is also the President of Innovative Biotech.

Author Contributions

Conceived and designed the experiments: SMA. Performed the experiments: SMA JCF FN TW JW RW. Analyzed the data: SMA JCF FN TW JW RW HW. Contributed reagents/materials/analysis tools: SMA JCF FN TW JW RW HW. Wrote the paper: SMA JCF FN TW JW RW HW. Read and approved the final version: SMA JCF FN TW JW RW HW.