About the Authors

Fabio Miyajima

Contributed equally to this work with: Fabio Miyajima, Paul Roberts

Affiliations National Institute for Health Research (NIHR) Biomedical Research Centre, Royal Liverpool and Broadgreen University Hospitals National Health Service (NHS) Trust, Liverpool, United Kingdom, Department of Pharmacology, The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, United Kingdom

Paul Roberts

Contributed equally to this work with: Fabio Miyajima, Paul Roberts

Affiliations National Institute for Health Research (NIHR) Biomedical Research Centre, Royal Liverpool and Broadgreen University Hospitals National Health Service (NHS) Trust, Liverpool, United Kingdom, Directorate of Infection and Immunity, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, United Kingdom

Andrew Swale

Affiliations National Institute for Health Research (NIHR) Biomedical Research Centre, Royal Liverpool and Broadgreen University Hospitals National Health Service (NHS) Trust, Liverpool, United Kingdom, Department of Pharmacology, The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, United Kingdom

Valerie Price

Affiliations National Institute for Health Research (NIHR) Biomedical Research Centre, Royal Liverpool and Broadgreen University Hospitals National Health Service (NHS) Trust, Liverpool, United Kingdom, Directorate of Infection and Immunity, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, United Kingdom

Maureen Jones

Affiliation Neurodegeneration Research Group, School of Community-Based Medicine, University of Manchester, Manchester, United Kingdom

Michael Horan

Affiliation Neurodegeneration Research Group, School of Community-Based Medicine, University of Manchester, Manchester, United Kingdom

Nicholas Beeching

Affiliations National Institute for Health Research (NIHR) Biomedical Research Centre, Royal Liverpool and Broadgreen University Hospitals National Health Service (NHS) Trust, Liverpool, United Kingdom, Clinical Group, Liverpool School of Tropical Medicine, University of Liverpool, Liverpool, United Kingdom

Jonathan Brazier

Affiliation Anaerobe Reference Unit, Public Health Laboratory, University Hospital Wales, Cardiff, United Kingdom

Christopher Parry

Affiliations National Institute for Health Research (NIHR) Biomedical Research Centre, Royal Liverpool and Broadgreen University Hospitals National Health Service (NHS) Trust, Liverpool, United Kingdom, Division of Clinical Infection, Microbiology and Immunology, Institute of Global Health, University of Liverpool, Liverpool, United Kingdom, Wellcome Trust Major Overseas Programme, Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand

Neil Pendleton

Affiliation Neurodegeneration Research Group, School of Community-Based Medicine, University of Manchester, Manchester, United Kingdom

Munir Pirmohamed

munirp@liv.ac.uk

Affiliations National Institute for Health Research (NIHR) Biomedical Research Centre, Royal Liverpool and Broadgreen University Hospitals National Health Service (NHS) Trust, Liverpool, United Kingdom, Department of Pharmacology, The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MP CP FM PHR NP MH. Performed the experiments: PHR FM AS VP JB. Analyzed the data: FM AS PHR. Contributed reagents/materials/analysis tools: MJ NP MH MP. Wrote the paper: FM PHR. Collection kits: FM AS. Facilitated recruitment: MJ NP MH. Clinical input: CP NP MH NB MP.