Early Elevation of Matrix Metalloproteinase-8 and -9 in Pediatric ARDS Is Associated with an Increased Risk of Prolonged Mechanical Ventilation

Michele Y. F. Kong; Yao Li; Robert Oster; Amit Gaggar; J. P. Clancy

doi:10.1371/journal.pone.0022596

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Open Access

Peer-reviewed

Research Article

Early Elevation of Matrix Metalloproteinase-8 and -9 in Pediatric ARDS Is Associated with an Increased Risk of Prolonged Mechanical Ventilation

Michele Y. F. Kong ,

* E-mail: mkong@peds.uab.edu

Affiliation Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Yao Li,

Affiliation Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Robert Oster,

Affiliation Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Amit Gaggar,

Affiliation Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
J. P. Clancy

Affiliation Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
⨯

Early Elevation of Matrix Metalloproteinase-8 and -9 in Pediatric ARDS Is Associated with an Increased Risk of Prolonged Mechanical Ventilation

Michele Y. F. Kong,
Yao Li,
Robert Oster,
Amit Gaggar,
J. P. Clancy

Published: August 3, 2011
https://doi.org/10.1371/journal.pone.0022596

About the Authors

Michele Y. F. Kong

* E-mail: mkong@peds.uab.edu

Affiliation Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Yao Li

Affiliation Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Robert Oster

Affiliation Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Amit Gaggar

Affiliation Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

J. P. Clancy

Affiliation Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MK JPC. Performed the experiments: MK YL. Analyzed the data: MK RO AG JPC. Contributed reagents/materials/analysis tools: MK JPC. Wrote the paper: MK RO AG JPC.

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Intubation
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Pediatrics
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Acute respiratory distress syndrome
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Ventilators
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Prisms
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Etiology
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Neutrophils
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