About the Authors
- Eric Z. Chen
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Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
- Rossa W. K. Chiu
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Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
- Hao Sun
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Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
- Ranjit Akolekar
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Affiliation Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, United Kingdom
- K. C. Allen Chan
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Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
- Tak Y. Leung
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Affiliation Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China
- Peiyong Jiang
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Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
- Yama W. L. Zheng
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Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
- Fiona M. F. Lun
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Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
- Lisa Y. S. Chan
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Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
- Yongjie Jin
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Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China
- Attie T. J. I. Go
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Affiliation VU University Medical Center, Amsterdam, The Netherlands
- Elizabeth T. Lau
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Affiliation Tsan Yuk Hospital, Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong SAR, China
- William W. K. To
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Affiliation United Christian Hospital, Hong Kong SAR, China
- Wing C. Leung
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Affiliation Kwong Wah Hospital, Hong Kong SAR, China
- Rebecca Y. K. Tang
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Affiliation Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China
- Sidney K. C. Au-Yeung
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Affiliation Tuen Mun Hospital, Hong Kong SAR, China
- Helena Lam
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Affiliation Princess Margaret Hospital, Hospital Authority, Hong Kong SAR, China
- Yu Y. Kung
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Affiliation YY Kung Medical Centre, Hong Kong SAR, China
- Xiuqing Zhang
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Affiliations Joint Chinese University of Hong Kong-Beijing Genomics Institute Genome Research Centre, Li Ka Shing Institute of Health Sciences, Hong Kong SAR, China, Beijing Genomics Institute at Shenzhen, Shenzhen, China
- John M. G. van Vugt
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Affiliation VU University Medical Center, Amsterdam, The Netherlands
- Ryoko Minekawa
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Affiliation Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, United Kingdom
- Mary H. Y. Tang
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Affiliation Tsan Yuk Hospital, Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong SAR, China
- Jun Wang
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Affiliations Joint Chinese University of Hong Kong-Beijing Genomics Institute Genome Research Centre, Li Ka Shing Institute of Health Sciences, Hong Kong SAR, China, Beijing Genomics Institute at Shenzhen, Shenzhen, China
- Cees B. M. Oudejans
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Affiliation VU University Medical Center, Amsterdam, The Netherlands
- Tze K. Lau
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Affiliation Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR, China
- Kypros H. Nicolaides
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Affiliation Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, United Kingdom
- Y. M. Dennis Lo
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* E-mail: loym@cuhk.edu.hk
Affiliations Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China, Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong SAR, China, Joint Chinese University of Hong Kong-Beijing Genomics Institute Genome Research Centre, Li Ka Shing Institute of Health Sciences, Hong Kong SAR, China
Competing Interests
The authors have read the journal's policy and have the following conflicts: RWKC, YWLZ, KCAC, FMFL and YMDL have filed patent applications on the detection of fetal nucleic acids in maternal plasma for noninvasive prenatal diagnosis. Part of this patent portfolio has been licensed to Sequenom. YMDL is a consultant to and holds equities in Sequenom. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: RWKC HS YMDL. Performed the experiments: EZC YWLZ FMFL LYSC YJ. Analyzed the data: EZC HS KCAC PJ. Contributed reagents/materials/analysis tools: RA TYL ATJIG ETL WWKT WCL RYKT SKCA-Y HL YYK JMGvV RM MHYT TKL CBMO KHN XZ JW. Wrote the paper: EZC RWKC HS YMDL. Designed the clinical recruitment protocols: TYL MHYT CBMO TKL KHN.