About the Authors

Steven C. Chen

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Ellie Frett

Current address: Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, United States of America

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Joseph Marx

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Darko Bosnakovski

Affiliation Lillehei Heart Institute and Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, United States of America

Xylena Reed

Current address: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Michael Kyba

Affiliation Lillehei Heart Institute and Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, United States of America

Brian K. Kennedy

bkennedy@buckinstitute.org

Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Buck Institute for Age Research, Novato, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SCC BKK. Performed the experiments: SCC EF JM XR. Analyzed the data: SCC EF JM XR BKK. Contributed reagents/materials/analysis tools: DB MK. Wrote the paper: SCC BKK.