About the Authors

Kelly J. Chandler

chandler.kelly@epa.gov

Affiliations National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America, National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

Marianne Barrier

Affiliation National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

Susan Jeffay

Affiliation National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

Harriette P. Nichols

Affiliation National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

Nicole C. Kleinstreuer

Affiliation National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

Amar V. Singh

Affiliation Lockheed Martin, Research Triangle Park, North Carolina, United States of America

David M. Reif

Affiliation National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

Nisha S. Sipes

Affiliation National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

Richard S. Judson

Affiliation National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

David J. Dix

Affiliation National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

Robert Kavlock

Affiliation National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

Edward S. Hunter III

Affiliation National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

Thomas B. Knudsen

Affiliation National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

Competing Interests

Lockheed Martin is a contractor to the EPA. This does not alter the authors' or Lockheed Martin's adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KC MB DD RK SH TK. Performed the experiments: KC SJ HN. Analyzed the data: KC MB AS. Contributed reagents/materials/analysis tools: NK DR RJ. Wrote the paper: KC. Edited the manuscript: MB NK AS DR NS RJ DD RK SH TK.