About the Authors
- Zhifu Sun
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Affiliation Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
- Yan W. Asmann
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Affiliation Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
- Krishna R. Kalari
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Affiliations Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America, Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida, United States of America
- Brian Bot
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Affiliation Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
- Jeanette E. Eckel-Passow
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Affiliation Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
- Tiffany R. Baker
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Affiliation Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida, United States of America
- Jennifer M. Carr
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Affiliation Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida, United States of America
- Irina Khrebtukova
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Affiliation Illumina, Inc., Hayward, California, United States of America
- Shujun Luo
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Affiliation Illumina, Inc., Hayward, California, United States of America
- Lu Zhang
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Affiliation Illumina, Inc., Hayward, California, United States of America
- Gary P. Schroth
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Affiliation Illumina, Inc., Hayward, California, United States of America
- Edith A. Perez
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Affiliation Department of Medicine, Mayo Clinic, Jacksonville, Florida, United States of America
- E. Aubrey Thompson
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* E-mail: thompson.aubrey@mayo.edu
Affiliation Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida, United States of America
Competing Interests
Z. Sun, Y. Asmann, K.R. Kalari, B. Bot, J. Eckel-Passow, T.R. Baker, J.M. Carr, E.A. Perez, and E.A. Thompson declare no conflict of interest. I. Khrebtukova, S. Luo, L. Zhang, and G.P. Schroth were employed by Illumina, Inc. at the time these experiments were carried out. Although all sequencing protocols were carried out on the Illumina Genome Analyzer, the central focus of this project is on library construction and data analysis, with no attempt to favor any particular next generation sequencing platform. Although they had roles in the study, this does not alter our adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: EAT YWA GPS. Performed the experiments: TRB JMC SL. Analyzed the data: ZS EAT. Wrote the manuscript: ZS EAT. Provided overall guidance for the project: YWA. Adapted the CNV-seq protocols: KRK. Provided statistical support: BB JEP. Provided the initial analyses of the sequence data: IK LZ. Guided our analysis of breast tumor samples and contributed to data interpretation and re-evaluation of our conclusions: EAP.