About the Authors

Roxana E. Iacob

Current address: Pfizer Inc., Cambridge, Boston, Massachusetts, United States of America

Affiliation Department of Chemistry & Chemical Biology, and The Barnett Institute for Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts, United States of America

Jianming Zhang

Affiliation Biological Chemistry & Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Nathanael S. Gray

Affiliation Biological Chemistry & Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

John R. Engen

j.engen@neu.edu

Affiliation Department of Chemistry & Chemical Biology, and The Barnett Institute for Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts: JRE is a consultant for the Waters Corporation and received support from the Waters Corporation in the form of some of the instrumentation used in this research. NSG received funding from the Novartis Institute of Biomedical Research for allosteric Bcr-Abl inhibitors. These relationships do not alter the authors' adherence to all of the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JRE NSG. Performed the experiments: REI JZ. Analyzed the data: REI JZ NSG JRE. Contributed reagents/materials/analysis tools: REI JZ NSG JRE. Wrote the paper: REI JRE.