Detection, Analysis and Clinical Validation of Chromosomal Aberrations by Multiplex Ligation-Dependent Probe Amplification in Chronic Leukemia

Adam Abdool; Amber C. Donahue; Jay G. Wohlgemuth; Chen-Hsiung Yeh

doi:10.1371/journal.pone.0015407

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Open Access

Peer-reviewed

Research Article

Detection, Analysis and Clinical Validation of Chromosomal Aberrations by Multiplex Ligation-Dependent Probe Amplification in Chronic Leukemia

Adam Abdool ,

Contributed equally to this work with: Adam Abdool, Amber C. Donahue

Affiliation Department of Hematology and Oncology, Quest Diagnostics Nichols Institute, San Juan Capistrano, California, United States of America
⨯
Amber C. Donahue ,

Contributed equally to this work with: Adam Abdool, Amber C. Donahue

Affiliation Department of Hematology and Oncology, Quest Diagnostics Nichols Institute, San Juan Capistrano, California, United States of America
⨯
Jay G. Wohlgemuth,

Affiliation Department of Hematology and Oncology, Quest Diagnostics Nichols Institute, San Juan Capistrano, California, United States of America
⨯
Chen-Hsiung Yeh

* E-mail: chenhsiung.x.yeh@questdiagnostics.com

Affiliation Department of Hematology and Oncology, Quest Diagnostics Nichols Institute, San Juan Capistrano, California, United States of America
⨯

Detection, Analysis and Clinical Validation of Chromosomal Aberrations by Multiplex Ligation-Dependent Probe Amplification in Chronic Leukemia

Adam Abdool,
Amber C. Donahue,
Jay G. Wohlgemuth,
Chen-Hsiung Yeh

Published: October 25, 2010
https://doi.org/10.1371/journal.pone.0015407

About the Authors

Adam Abdool

Contributed equally to this work with: Adam Abdool, Amber C. Donahue

Affiliation Department of Hematology and Oncology, Quest Diagnostics Nichols Institute, San Juan Capistrano, California, United States of America

Amber C. Donahue

Contributed equally to this work with: Adam Abdool, Amber C. Donahue

Affiliation Department of Hematology and Oncology, Quest Diagnostics Nichols Institute, San Juan Capistrano, California, United States of America

Jay G. Wohlgemuth

Affiliation Department of Hematology and Oncology, Quest Diagnostics Nichols Institute, San Juan Capistrano, California, United States of America

Chen-Hsiung Yeh

* E-mail: chenhsiung.x.yeh@questdiagnostics.com

Affiliation Department of Hematology and Oncology, Quest Diagnostics Nichols Institute, San Juan Capistrano, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CH JW. Performed the experiments: AA AD. Analyzed the data: AA AD. Contributed reagents/materials/analysis tools: CH AA AD. Wrote the paper: CH JW.

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Chronic lymphoblastic leukemia
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Fluorescent in situ hybridization
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Signal amplification
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Leukemia
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Chromosomal deletions
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Diagnostic medicine
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Fish genomics
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Polymerase chain reaction
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