PGE2 Induces IL-6 in Orbital Fibroblasts through EP2 Receptors and Increased Gene Promoter Activity: Implications to Thyroid-Associated Ophthalmopathy

Nupur Raychaudhuri; Raymond S. Douglas; Terry J. Smith

doi:10.1371/journal.pone.0015296

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Open Access

Peer-reviewed

Research Article

PGE₂ Induces IL-6 in Orbital Fibroblasts through EP2 Receptors and Increased Gene Promoter Activity: Implications to Thyroid-Associated Ophthalmopathy

Nupur Raychaudhuri,

Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
⨯
Raymond S. Douglas,

Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
⨯
Terry J. Smith

* E-mail: terrysmi@med.umich.edu

Affiliation Department of Ophthalmology and Visual Sciences and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
⨯

PGE₂ Induces IL-6 in Orbital Fibroblasts through EP2 Receptors and Increased Gene Promoter Activity: Implications to Thyroid-Associated Ophthalmopathy

Nupur Raychaudhuri,
Raymond S. Douglas,
Terry J. Smith

Published: December 23, 2010
https://doi.org/10.1371/journal.pone.0015296

About the Authors

Nupur Raychaudhuri

Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Raymond S. Douglas

Affiliation Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Terry J. Smith

* E-mail: terrysmi@med.umich.edu

Affiliation Department of Ophthalmology and Visual Sciences and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TJS RSD NR. Performed the experiments: NR. Analyzed the data: TJS RSD NR. Wrote the paper: TJS NR.

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Fibroblasts
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Small interfering RNA
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Enzyme-linked immunoassays
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Immunoprecipitation
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Phosphorylation
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Cytokines
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Transfection
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Adenylyl cyclase
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