About the Authors

Jianmin Xue

Contributed equally to this work with: Jianmin Xue, Bernadette R. Gochuico

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Bernadette R. Gochuico

Contributed equally to this work with: Jianmin Xue, Bernadette R. Gochuico

Affiliation Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Ahmad Samer Alawad

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Carol A. Feghali-Bostwick

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Imre Noth

Affiliation Department of Medicine, University of Chicago Medical Center, Chicago, Illinois, United States of America

Steven D. Nathan

Affiliation Advanced Lung Disease Program, Inova Fairfax Hospital, Falls Church, Virginia, United States of America

Glenn D. Rosen

Affiliation Department of Medicine, Stanford University Medical Center, Stanford, California, United States of America

Ivan O. Rosas

Affiliation Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Sanja Dacic

Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Iclal Ocak

Affiliation Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Carl R. Fuhrman

Affiliation Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Karen T. Cuenco

Affiliation Department of Oral Biology-Dental Medicine and Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Mary A. Smith

Affiliation Advanced Lung Disease Program, Inova Fairfax Hospital, Falls Church, Virginia, United States of America

Susan S. Jacobs

Affiliation Department of Medicine, Stanford University Medical Center, Stanford, California, United States of America

Adriana Zeevi

Affiliation Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Penelope A. Morel

Affiliation Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Joseph M. Pilewski

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Vincent G. Valentine

Affiliation Department of Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America

Kevin F. Gibson

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Naftali Kaminski

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Frank C. Sciurba

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Yingze Zhang

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Steven R. Duncan

duncsr@upmc.edu

Affiliation Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JX IOR VGV YZ SD. Performed the experiments: JX BRG ASA CFB SDN GR IOR SD IO CF MAS SSJ AZ PAM JMP FCS YZ SD. Analyzed the data: BRG ASA CFB IN SDN GR IOR SD IO CF KC MAS SSJ AZ PAM JMP VGV FCS YZ SD. Contributed reagents/materials/analysis tools: BRG ASA CFB IN SDN GR IOR SD IO CF KC MAS SSJ AZ PAM JMP VGV KFG NK FCS YZ SD. Wrote the paper: JX KC PAM KFG SD. Proofed and/or edited paper: JX BG AS CF-B SDN GR SD IO CF KC MAS SSJ AZ JMP VGV KFG NK YZ FCS Performed the brunt of the specimen processing, DNA extraction, HLA assays and validations of same. Assisted with data interpretations and analyses: JX. Identified NIH normal and IPF subjects, recruited them, obtained and processed specimens, and compiled and analyzed relevant clinical and HLA data for this validation cohort: BG. Assisted with specimen collation, DNA purification from same, and with HLA assays: AS. Assisted with HLA typing assays, contributed to experimental design features: CF-B. Identified Inova IPF subjects, enrolled them, obtained and processed specimens, and compiled and analyzed relevant clinical data for a validation cohort: SDN. Identified Stanford IPF subjects, enrolled them, obtained and processed specimens, and compiled and analyzed relevant clinical data for a validation cohort: GR. Performed blinded interpreations of surgical pathology specimens that validated their diagnoses of IPF: SD. In conjunction with Dr. Fuhrman, interpreted and validated chest CT scans of IPF patients: IO. Provided blinded radiographic validations of IPF chest CT scans: CF. Provided information critical for study design, assisted with and validated data analyses: KC. In conjunction with Dr. Nathan, identified Inova subjects, enrolled them, obtained and processed specimens, and compiled and analyzed relevant clinical data for a validation cohort from Inova: MAS. In conjunction with Dr. Rosen, identified Stanford subjects, enrolled them, obtained and processed specimens, and compiled and analyzed relevant clinical data for a validation cohort from Stanford: SSJ. Obtained and processed specimens of the U. Pgh. transplant population, performed HLA analyses of same. Provided additional specimens for high resolution typing as well as technical advice: AZ. Identified control subjects, enrolled them, obtained and processed specimens, performed HLA analyses, and compiled and analyzed relevant clinical data for the initial discovery control cohort. Assisted with data interpretations and manuscript writing: PAM. Identified transplant recipient subjects, enrolled them, obtained and processed specimens, and compiled and analyzed relevant clinical data for the initial IPF discovery cohort. Facilitated or procured specimen acquisitions from same: JMP. Analyzed data, assisted with study design and identifications of collaborators and validation cohorts. Assisted with data analyses. Procured additional data: VGV. Identified ambulatory IPF subjects, recruited them for these studies, obtained and processed specimens, and compiled and analyzed relevant clinical data for this validation cohort: KFG NK. Provided technical assistance and advice. Helped with DNA isolation and analyses: YZ. Identified normal volunteer subjects, enrolled them, obtained and processed specimens, and compiled and analyzed relevant clinical data for a validation control cohort: FCS. Conceived and designed experiments, coordinated specimen acquistion, processing and analyses, collated clinical information provided by colleagues, analyzed the data in conjunction with co-authors, provided financial support of the studies, and wrote the paper: SRD.