Identification of Histone Deacetylase 3 as a Biomarker for Tumor Recurrence Following Liver Transplantation in HBV-Associated Hepatocellular Carcinoma

Li-Ming Wu; Zhe Yang; Lin Zhou; Feng Zhang; Hai-Yang Xie; Xiao-Wen Feng; Jian Wu; Shu-Sen Zheng

doi:10.1371/journal.pone.0014460

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Open Access

Peer-reviewed

Research Article

Identification of Histone Deacetylase 3 as a Biomarker for Tumor Recurrence Following Liver Transplantation in HBV-Associated Hepatocellular Carcinoma

Li-Ming Wu ,

Contributed equally to this work with: Li-Ming Wu, Zhe Yang, Lin Zhou

Affiliation Key Lab of Combined Multi-Organ Transplantation, Key Lab of Organ Transplantation, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Zhe Yang ,

Contributed equally to this work with: Li-Ming Wu, Zhe Yang, Lin Zhou

Affiliation Key Lab of Combined Multi-Organ Transplantation, Key Lab of Organ Transplantation, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Lin Zhou ,

Contributed equally to this work with: Li-Ming Wu, Zhe Yang, Lin Zhou

Affiliation Key Lab of Combined Multi-Organ Transplantation, Key Lab of Organ Transplantation, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Feng Zhang,

Affiliation Key Lab of Combined Multi-Organ Transplantation, Key Lab of Organ Transplantation, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Hai-Yang Xie,

Affiliation Key Lab of Combined Multi-Organ Transplantation, Key Lab of Organ Transplantation, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Xiao-Wen Feng,

Affiliation Key Lab of Combined Multi-Organ Transplantation, Key Lab of Organ Transplantation, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Jian Wu,

Affiliation Key Lab of Combined Multi-Organ Transplantation, Key Lab of Organ Transplantation, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Shu-Sen Zheng

* E-mail: shusenzheng@zju.edu.cn

Affiliation Key Lab of Combined Multi-Organ Transplantation, Key Lab of Organ Transplantation, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯

Identification of Histone Deacetylase 3 as a Biomarker for Tumor Recurrence Following Liver Transplantation in HBV-Associated Hepatocellular Carcinoma

Li-Ming Wu,
Zhe Yang,
Lin Zhou,
Feng Zhang,
Hai-Yang Xie,
Xiao-Wen Feng,
Jian Wu,
Shu-Sen Zheng

Published: December 29, 2010
https://doi.org/10.1371/journal.pone.0014460

About the Authors

Li-Ming Wu

Contributed equally to this work with: Li-Ming Wu, Zhe Yang, Lin Zhou

Affiliation Key Lab of Combined Multi-Organ Transplantation, Key Lab of Organ Transplantation, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

Zhe Yang

Contributed equally to this work with: Li-Ming Wu, Zhe Yang, Lin Zhou

Lin Zhou

Contributed equally to this work with: Li-Ming Wu, Zhe Yang, Lin Zhou

Feng Zhang

Hai-Yang Xie

Xiao-Wen Feng

Jian Wu

Shu-Sen Zheng

* E-mail: shusenzheng@zju.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LMW ZY SSZ. Performed the experiments: LMW ZY FZ XWF. Analyzed the data: LMW ZY LZ. Contributed reagents/materials/analysis tools: LMW ZY LZ FZ HYX JW. Wrote the paper: LMW ZY LZ JW SSZ.

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Hepatocellular carcinoma
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Cancer treatment
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Small interfering RNA
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Malignant tumors
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Prostate cancer
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Metastasis
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Cell cycle and cell division
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Liver transplantation
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