Gene Regulatory Networks from Multifactorial Perturbations Using Graphical Lasso: Application to the DREAM4 Challenge

Patricia Menéndez; Yiannis A. I. Kourmpetis; Cajo J. F. ter Braak; Fred A. van Eeuwijk

doi:10.1371/journal.pone.0014147

Loading metrics

Open Access

Peer-reviewed

Research Article

Gene Regulatory Networks from Multifactorial Perturbations Using Graphical Lasso: Application to the DREAM4 Challenge

Patricia Menéndez,

Affiliations Biometris, Wageningen University, Wageningen, The Netherlands, Centre for BioSystems Genetics, Wageningen, The Netherlands
⨯
Yiannis A. I. Kourmpetis,

Affiliations Biometris, Wageningen University, Wageningen, The Netherlands, Laboratory of Bioinformatics, Wageningen University, Wageningen, The Netherlands
⨯
Cajo J. F. ter Braak ,

* E-mail: cajo.terbraak@wur.nl

Affiliation Biometris, Wageningen University, Wageningen, The Netherlands
⨯
Fred A. van Eeuwijk

Affiliations Biometris, Wageningen University, Wageningen, The Netherlands, Centre for BioSystems Genetics, Wageningen, The Netherlands
⨯

Gene Regulatory Networks from Multifactorial Perturbations Using Graphical Lasso: Application to the DREAM4 Challenge

Patricia Menéndez,
Yiannis A. I. Kourmpetis,
Cajo J. F. ter Braak,
Fred A. van Eeuwijk

Published: December 20, 2010
https://doi.org/10.1371/journal.pone.0014147

About the Authors

Patricia Menéndez

Affiliations Biometris, Wageningen University, Wageningen, The Netherlands, Centre for BioSystems Genetics, Wageningen, The Netherlands

Yiannis A. I. Kourmpetis

Affiliations Biometris, Wageningen University, Wageningen, The Netherlands, Laboratory of Bioinformatics, Wageningen University, Wageningen, The Netherlands

Cajo J. F. ter Braak

* E-mail: cajo.terbraak@wur.nl

Affiliation Biometris, Wageningen University, Wageningen, The Netherlands

Fred A. van Eeuwijk

Affiliations Biometris, Wageningen University, Wageningen, The Netherlands, Centre for BioSystems Genetics, Wageningen, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PM YK CJFtB FvE. Performed the experiments: PM YK CJFtB FvE. Analyzed the data: PM YK CJFtB FvE. Contributed reagents/materials/analysis tools: PM YK CJFtB FvE. Wrote the paper: PM YK CJFtB FvE.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Covariance
Is the Subject Area "Covariance" applicable to this article?

Thanks for your feedback.
Genetic networks
Is the Subject Area "Genetic networks" applicable to this article?

Thanks for your feedback.
Gene regulatory networks
Is the Subject Area "Gene regulatory networks" applicable to this article?

Thanks for your feedback.
Algorithms
Is the Subject Area "Algorithms" applicable to this article?

Thanks for your feedback.
Network analysis
Is the Subject Area "Network analysis" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Topology
Is the Subject Area "Topology" applicable to this article?

Thanks for your feedback.
Systems biology
Is the Subject Area "Systems biology" applicable to this article?

Thanks for your feedback.