1,25-Dihydroxyvitamin D3 Inhibits the Differentiation and Migration of TH17 Cells to Protect against Experimental Autoimmune Encephalomyelitis

Jae-Hoon Chang; Hye-Ran Cha; Dong-Sup Lee; Kyoung Yul Seo; Mi-Na Kweon

doi:10.1371/journal.pone.0012925

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Open Access

Peer-reviewed

Research Article

1,25-Dihydroxyvitamin D₃ Inhibits the Differentiation and Migration of T_H17 Cells to Protect against Experimental Autoimmune Encephalomyelitis

Jae-Hoon Chang,

Affiliation Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea
⨯
Hye-Ran Cha,

Affiliation Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea
⨯
Dong-Sup Lee,

Affiliation Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
⨯
Kyoung Yul Seo,

Affiliations Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea, Department of Ophthalmology, Institute for Vision Research, Yonsei University College of Medicine, Seoul, Korea
⨯
Mi-Na Kweon

* E-mail: mnkweon@ivi.int

Affiliation Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea
⨯

1,25-Dihydroxyvitamin D₃ Inhibits the Differentiation and Migration of T_H17 Cells to Protect against Experimental Autoimmune Encephalomyelitis

Jae-Hoon Chang,
Hye-Ran Cha,
Dong-Sup Lee,
Kyoung Yul Seo,
Mi-Na Kweon

Published: September 23, 2010
https://doi.org/10.1371/journal.pone.0012925

About the Authors

Jae-Hoon Chang

Affiliation Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea

Hye-Ran Cha

Affiliation Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea

Dong-Sup Lee

Affiliation Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea

Kyoung Yul Seo

Affiliations Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea, Department of Ophthalmology, Institute for Vision Research, Yonsei University College of Medicine, Seoul, Korea

Mi-Na Kweon

* E-mail: mnkweon@ivi.int

Affiliation Mucosal Immunology Section, Laboratory Science Division, International Vaccine Institute, Seoul, Korea

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JHC MNK. Performed the experiments: JHC HRC. Analyzed the data: JHC HRC. Contributed reagents/materials/analysis tools: JHC HRC DSL KYS. Wrote the paper: JHC.

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T cells
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Vitamins
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Cell differentiation
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Regulatory T cells
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Multiple sclerosis
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Central nervous system
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Signal inhibition
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Vitamin D
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