About the Authors

Elizabeth A. Punnoose

punnoose.elizabeth@gene.com

Affiliation Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America

Siminder K. Atwal

Affiliation Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America

Jill M. Spoerke

Affiliation Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America

Heidi Savage

Affiliation Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America

Ajay Pandita

Affiliation Department of Molecular Diagnostics and Cancer Cell Biology, Genentech, Inc., South San Francisco, California, United States of America

Ru-Fang Yeh

Affiliation Department of Biostatistics, Genentech, Inc., South San Francisco, California, United States of America

Andrea Pirzkall

Affiliation Department of Oncology Exploratory Clinical Development, Genentech, Inc., South San Francisco, California, United States of America

Bernard M. Fine

Affiliation Department of Oncology Exploratory Clinical Development, Genentech, Inc., South San Francisco, California, United States of America

Lukas C. Amler

Affiliation Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America

Daniel S. Chen

Affiliation Department of Oncology Exploratory Clinical Development, Genentech, Inc., South San Francisco, California, United States of America

Mark R. Lackner

Affiliation Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America

Competing Interests

This study was funded fully by Genentech but there is no competing interest that can bias this work. This affiliation, however, does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EAP BMF LCA DSC MRL. Performed the experiments: EAP SKA JMS HS. Analyzed the data: EAP SKA JMS HS AP RFY. Contributed reagents/materials/analysis tools: AP AP. Wrote the paper: EAP MRL. Overall project scope and strategy: DSC MRL.