About the Authors
- Hanna Y. Irie
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Affiliations Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
- Yashaswi Shrestha
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Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
- Laura M. Selfors
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Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
- Fabianne Frye
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Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
- Naoko Iida
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Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
- Zhigang Wang
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Affiliation Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
- Lihua Zou
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Affiliation Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
- Jun Yao
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Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
- Yiling Lu
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Affiliation Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
- Charles B. Epstein
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Affiliations Sanofi-Aventis, Cambridge, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America
- Sridaran Natesan
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Affiliation Sanofi-Aventis, Cambridge, Massachusetts, United States of America
- Andrea L. Richardson
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Affiliation Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
- Kornelia Polyak
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Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
- Gordon B. Mills
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Affiliation Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
- William C. Hahn
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Affiliations Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America
- Joan S. Brugge
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* E-mail: Joan_Brugge@hms.harvard.edu
Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
Competing Interests
This work was partially funded by a grant from Sanofi-Aventis to Joan Brugge. We declare that there are no restrictions on sharing any of the data or reagents used in this study in accordance with the policies of PLoS ONE.
Author Contributions
Conceived and designed the experiments: HI YS JSB. Performed the experiments: HI YS FF NI ZW YL. Analyzed the data: HI YS LS ZW LZ JY ALR KP GM WCH JSB. Contributed reagents/materials/analysis tools: HI YS LS YL CBE SN KP. Wrote the paper: HI LS JSB.