About the Authors

Hanna Y. Irie

Affiliations Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Yashaswi Shrestha

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Laura M. Selfors

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Fabianne Frye

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Naoko Iida

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Zhigang Wang

Affiliation Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Lihua Zou

Affiliation Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Jun Yao

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Yiling Lu

Affiliation Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Charles B. Epstein

Affiliations Sanofi-Aventis, Cambridge, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

Sridaran Natesan

Affiliation Sanofi-Aventis, Cambridge, Massachusetts, United States of America

Andrea L. Richardson

Affiliation Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

Kornelia Polyak

Affiliation Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

Gordon B. Mills

Affiliation Department of Systems Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

William C. Hahn

Affiliations Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, United States of America

Joan S. Brugge

Joan_Brugge@hms.harvard.edu

Affiliation Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

This work was partially funded by a grant from Sanofi-Aventis to Joan Brugge. We declare that there are no restrictions on sharing any of the data or reagents used in this study in accordance with the policies of PLoS ONE.

Author Contributions

Conceived and designed the experiments: HI YS JSB. Performed the experiments: HI YS FF NI ZW YL. Analyzed the data: HI YS LS ZW LZ JY ALR KP GM WCH JSB. Contributed reagents/materials/analysis tools: HI YS LS YL CBE SN KP. Wrote the paper: HI LS JSB.