I-Motif Structures Formed in the Human c-MYC Promoter Are Highly Dynamic–Insights into Sequence Redundancy and I-Motif Stability

Jixun Dai; Emmanuel Hatzakis; Laurence H. Hurley; Danzhou Yang

doi:10.1371/journal.pone.0011647

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Peer-reviewed

Research Article

I-Motif Structures Formed in the Human c-MYC Promoter Are Highly Dynamic–Insights into Sequence Redundancy and I-Motif Stability

Jixun Dai,

Affiliation College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America
⨯
Emmanuel Hatzakis,

Affiliation College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America
⨯
Laurence H. Hurley,

Affiliations College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America, BIO5 Institute, The University of Arizona, Tucson, Arizona, United States of America, Arizona Cancer Center, The University of Arizona, Tucson, Arizona, United States of America, Department of Chemistry, The University of Arizona, Tucson, Arizona, United States of America
⨯
Danzhou Yang

* E-mail: yang@pharmacy.arizona.edu

Affiliations College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America, BIO5 Institute, The University of Arizona, Tucson, Arizona, United States of America, Arizona Cancer Center, The University of Arizona, Tucson, Arizona, United States of America, Department of Chemistry, The University of Arizona, Tucson, Arizona, United States of America
⨯

I-Motif Structures Formed in the Human c-MYC Promoter Are Highly Dynamic–Insights into Sequence Redundancy and I-Motif Stability

Jixun Dai,
Emmanuel Hatzakis,
Laurence H. Hurley,
Danzhou Yang

Published: July 19, 2010
https://doi.org/10.1371/journal.pone.0011647

About the Authors

Jixun Dai

Affiliation College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America

Emmanuel Hatzakis

Affiliation College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America

Laurence H. Hurley

Affiliations College of Pharmacy, The University of Arizona, Tucson, Arizona, United States of America, BIO5 Institute, The University of Arizona, Tucson, Arizona, United States of America, Arizona Cancer Center, The University of Arizona, Tucson, Arizona, United States of America, Department of Chemistry, The University of Arizona, Tucson, Arizona, United States of America

Danzhou Yang

* E-mail: yang@pharmacy.arizona.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JD LH DY. Performed the experiments: JD EH. Analyzed the data: JD EH DY. Wrote the paper: JD DY.

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Cytosine
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Protons
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Isomers
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Melting
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NMR spectroscopy
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DNA structure
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Oligonucleotides
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One-dimensional NMR spectroscopy
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