About the Authors

Kristen N. Stevens

Affiliation Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America

Hakon Hakonarson

Affiliation The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Cecilia E. Kim

Affiliation The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Pieter A. Doevendans

Affiliation Department of Cardiology, UMC Utrecht, Utrecht, The Netherlands

Bobby P. C. Koeleman

Affiliation Department of Medical Genetics, UMC Utrecht, Utrecht, The Netherlands

Seema Mital

Affiliation Heart Center, Hospital for Sick Children, Toronto, Ontario, Canada

Jennifer Raue

Affiliation The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Joseph T. Glessner

Affiliation The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

John G. Coles

Affiliation Heart Center, Hospital for Sick Children, Toronto, Ontario, Canada

Victor Moreno

Affiliation Biostatistics and Bioinformatics Unit, IDIBELL-Catalan Institute of Oncology and University of Barcelona, L'Hospitalet del Llobregat, Barcelona, Spain

Anne Granger

Affiliation The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Stephen B. Gruber

sgruber@umich.edu (SBG); pgruber@mail.med.upenn.edu (PJG)

Affiliations Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

Peter J. Gruber

sgruber@umich.edu (SBG); pgruber@mail.med.upenn.edu (PJG)

Affiliations The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Institute for Regenerative Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SBG PJG. Performed the experiments: KNS CEK AG. Analyzed the data: KNS VM SBG PJG. Contributed reagents/materials/analysis tools: HH CEK PAD BPCK SM JTG JC VM PJG. Wrote the paper: KNS SBG PJG. Recruited patients: JR. Originated and designed the project, analyzed the results: PJG. Co-wrote the manuscript: PJG KNS SBG. Provided guidance, design, and support throughout the project: KNS SBG. At the Center for Applied Genomics performed the genotyping and control populations providing selected data to PJG and SBG: HH CEK JTG. Supervised the data analysis: JTG VM SBG. Performed all of the sequencing, custom genotyping and analytic programming: KNS. Coordinated the clinical collection of samples: PJG JR. Was involved in preliminary experiments: AG. Provided samples from Toronto: SM JGC. Provided samples from the Netherlands: PAD BPCK.