Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

Najwane Saïd-Sadier; Eduardo Padilla; Gordon Langsley; David M. Ojcius

doi:10.1371/journal.pone.0010008

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Open Access

Peer-reviewed

Research Article

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

Najwane Saïd-Sadier,

Affiliations Health Sciences Research Institute and School of Natural Sciences, University of California Merced, Merced, California, United States of America, Graduate Group “Biochimie, Biothérapies, Biologie Moléculaire et Infectiologie”, Université Paris Diderot, Paris, France
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Eduardo Padilla,

Affiliation Health Sciences Research Institute and School of Natural Sciences, University of California Merced, Merced, California, United States of America
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Gordon Langsley,

Affiliations Graduate Group “Biochimie, Biothérapies, Biologie Moléculaire et Infectiologie”, Université Paris Diderot, Paris, France, Institut Cochin, Université Paris Descartes, CNRS UMR 8104, INSERM U1016, Paris, France
⨯
David M. Ojcius

* E-mail: david.ojcius@gmail.com

Affiliation Health Sciences Research Institute and School of Natural Sciences, University of California Merced, Merced, California, United States of America
⨯

Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase

Najwane Saïd-Sadier,
Eduardo Padilla,
Gordon Langsley,
David M. Ojcius

Published: April 2, 2010
https://doi.org/10.1371/journal.pone.0010008

About the Authors

Najwane Saïd-Sadier

Affiliations Health Sciences Research Institute and School of Natural Sciences, University of California Merced, Merced, California, United States of America, Graduate Group “Biochimie, Biothérapies, Biologie Moléculaire et Infectiologie”, Université Paris Diderot, Paris, France

Eduardo Padilla

Affiliation Health Sciences Research Institute and School of Natural Sciences, University of California Merced, Merced, California, United States of America

Gordon Langsley

Affiliations Graduate Group “Biochimie, Biothérapies, Biologie Moléculaire et Infectiologie”, Université Paris Diderot, Paris, France, Institut Cochin, Université Paris Descartes, CNRS UMR 8104, INSERM U1016, Paris, France

David M. Ojcius

* E-mail: david.ojcius@gmail.com

Affiliation Health Sciences Research Institute and School of Natural Sciences, University of California Merced, Merced, California, United States of America

Competing Interests

David Ojcius and Gordon Langsley are members of the PLoS ONE editorial board.

Author Contributions

Conceived and designed the experiments: DO. Performed the experiments: NSS EP. Analyzed the data: NSS. Contributed reagents/materials/analysis tools: GL DO. Wrote the paper: NSS GL DO.

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Aspergillus fumigatus
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Secretion
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Inflammasomes
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Cytokines
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Immune receptor signaling
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Monocytes
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Immune response
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Aspergillus
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