Mutations in the DNA-Binding Domain of NR2E3 Affect In Vivo Dimerization and Interaction with CRX

Raphael Roduit; Pascal Escher; Daniel F. Schorderet

doi:10.1371/journal.pone.0007379

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Open Access

Peer-reviewed

Research Article

Mutations in the DNA-Binding Domain of NR2E3 Affect In Vivo Dimerization and Interaction with CRX

Raphael Roduit ,

Contributed equally to this work with: Raphael Roduit, Pascal Escher

* E-mail: raphael.roduit@irovision.ch

Affiliations IRO, Institute for Research in Ophthalmology, Sion, Switzerland, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland
⨯
Pascal Escher ,

Contributed equally to this work with: Raphael Roduit, Pascal Escher

Affiliations IRO, Institute for Research in Ophthalmology, Sion, Switzerland, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland
⨯
Daniel F. Schorderet

Affiliations IRO, Institute for Research in Ophthalmology, Sion, Switzerland, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland, EPFL, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
⨯

Mutations in the DNA-Binding Domain of NR2E3 Affect In Vivo Dimerization and Interaction with CRX

Raphael Roduit,
Pascal Escher,
Daniel F. Schorderet

Published: October 12, 2009
https://doi.org/10.1371/journal.pone.0007379

About the Authors

Raphael Roduit

Contributed equally to this work with: Raphael Roduit, Pascal Escher

* E-mail: raphael.roduit@irovision.ch

Affiliations IRO, Institute for Research in Ophthalmology, Sion, Switzerland, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland

Pascal Escher

Contributed equally to this work with: Raphael Roduit, Pascal Escher

Affiliations IRO, Institute for Research in Ophthalmology, Sion, Switzerland, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland

Daniel F. Schorderet

Affiliations IRO, Institute for Research in Ophthalmology, Sion, Switzerland, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland, EPFL, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RR PAE. Performed the experiments: RR PAE. Analyzed the data: RR. Contributed reagents/materials/analysis tools: DFS. Wrote the paper: RR PAE DFS.

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Transfection
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DNA-binding proteins
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Dimerization
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Transactivation
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Luciferase
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Photoreceptors
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Protein interactions
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Mutation
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