About the Authors

Stephanie E. Hesselson

Contributed equally to this work with: Stephanie E. Hesselson, Pär Matsson, James E. Shima, Hisayo Fukushima

Affiliation Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

Pär Matsson

Contributed equally to this work with: Stephanie E. Hesselson, Pär Matsson, James E. Shima, Hisayo Fukushima

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

James E. Shima

Contributed equally to this work with: Stephanie E. Hesselson, Pär Matsson, James E. Shima, Hisayo Fukushima

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Hisayo Fukushima

Contributed equally to this work with: Stephanie E. Hesselson, Pär Matsson, James E. Shima, Hisayo Fukushima

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Sook Wah Yee

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Yuya Kobayashi

Affiliation Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

Jason M. Gow

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Connie Ha

Affiliation Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

Benjamin Ma

Affiliation Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

Annie Poon

Affiliation Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

Susan J. Johns

Affiliation Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

Doug Stryke

Affiliation Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

Richard A. Castro

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Harunobu Tahara

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Ji Ha Choi

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Ligong Chen

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Nicolas Picard

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Elin Sjödin

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Maarke J. E. Roelofs

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Thomas E. Ferrin

Affiliation Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

Richard Myers

Affiliation Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

Deanna L. Kroetz

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Pui-Yan Kwok

Affiliation Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

Kathleen M. Giacomini

kathy.giacomini@ucsf.edu

Affiliation Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SEH HF SWY YK JMG HT RMM DLK PYK KMG. Performed the experiments: SEH HF SWY YK JMG CH BM AP RAC HT JHC LC NP ES MJER. Analyzed the data: SEH PM JES HF YK SJJ DS TF RMM DLK PYK KMG. Contributed reagents/materials/analysis tools: DLK KMG. Wrote the paper: SEH PM JES HF SWY RMM DLK PYK KMG.