Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab

Alejandro Vazquez-Martin; Cristina Oliveras-Ferraros; Javier A. Menendez

doi:10.1371/journal.pone.0006251

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Open Access

Peer-reviewed

Research Article

Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab

Alejandro Vazquez-Martin,

Affiliations Catalan Institute of Oncology (ICO), Girona, Catalonia, Spain, Girona Biomedical Research Institute (IdIBGi), Dr. Josep Trueta University Hospital of Girona, Girona, Catalonia, Spain
⨯
Cristina Oliveras-Ferraros,

Affiliations Catalan Institute of Oncology (ICO), Girona, Catalonia, Spain, Girona Biomedical Research Institute (IdIBGi), Dr. Josep Trueta University Hospital of Girona, Girona, Catalonia, Spain
⨯
Javier A. Menendez

* E-mail: jmenendez@iconcologia.net

Affiliations Catalan Institute of Oncology (ICO), Girona, Catalonia, Spain, Girona Biomedical Research Institute (IdIBGi), Dr. Josep Trueta University Hospital of Girona, Girona, Catalonia, Spain
⨯

Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab

Alejandro Vazquez-Martin,
Cristina Oliveras-Ferraros,
Javier A. Menendez

Published: July 16, 2009
https://doi.org/10.1371/journal.pone.0006251

About the Authors

Alejandro Vazquez-Martin

Affiliations Catalan Institute of Oncology (ICO), Girona, Catalonia, Spain, Girona Biomedical Research Institute (IdIBGi), Dr. Josep Trueta University Hospital of Girona, Girona, Catalonia, Spain

Cristina Oliveras-Ferraros

Affiliations Catalan Institute of Oncology (ICO), Girona, Catalonia, Spain, Girona Biomedical Research Institute (IdIBGi), Dr. Josep Trueta University Hospital of Girona, Girona, Catalonia, Spain

Javier A. Menendez

* E-mail: jmenendez@iconcologia.net

Affiliations Catalan Institute of Oncology (ICO), Girona, Catalonia, Spain, Girona Biomedical Research Institute (IdIBGi), Dr. Josep Trueta University Hospital of Girona, Girona, Catalonia, Spain

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AVM JAM. Performed the experiments: AVM COF. Analyzed the data: AVM COF JAM. Contributed reagents/materials/analysis tools: JAM. Wrote the paper: JAM.

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Autophagic cell death
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Breast cancer
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Cancer treatment
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Immunoblotting
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Small interfering RNA
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Antibody therapy
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Monoclonal antibodies
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Transfection
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