About the Authors

Wenping Zhang

Contributed equally to this work with: Wenping Zhang, Zhengbing Lv

Affiliations Institute of Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, China, The Key Laboratory of Bioreactor and Biopharmacy of Zhejiang Province, Institute of Biochemistry, Zhejiang Sci-Tech University, Hangzhou, China

Zhengbing Lv

Contributed equally to this work with: Wenping Zhang, Zhengbing Lv

Affiliation The Key Laboratory of Bioreactor and Biopharmacy of Zhejiang Province, Institute of Biochemistry, Zhejiang Sci-Tech University, Hangzhou, China

Zuoming Nie

Affiliation The Key Laboratory of Bioreactor and Biopharmacy of Zhejiang Province, Institute of Biochemistry, Zhejiang Sci-Tech University, Hangzhou, China

Guogang Chen

Affiliation Zhejiang Chinagene Biopharmaceutical Co., Ltd., Haining, China

Jian Chen

Affiliation The Key Laboratory of Bioreactor and Biopharmacy of Zhejiang Province, Institute of Biochemistry, Zhejiang Sci-Tech University, Hangzhou, China

Qing Sheng

Affiliation The Key Laboratory of Bioreactor and Biopharmacy of Zhejiang Province, Institute of Biochemistry, Zhejiang Sci-Tech University, Hangzhou, China

Wei Yu

Affiliation The Key Laboratory of Bioreactor and Biopharmacy of Zhejiang Province, Institute of Biochemistry, Zhejiang Sci-Tech University, Hangzhou, China

Yongfeng Jin

Affiliation Institute of Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, China

Xiangfu Wu

Affiliations The Key Laboratory of Bioreactor and Biopharmacy of Zhejiang Province, Institute of Biochemistry, Zhejiang Sci-Tech University, Hangzhou, China, Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai, China

Yaozhou Zhang

yaozhou@chinagene.com

Affiliation The Key Laboratory of Bioreactor and Biopharmacy of Zhejiang Province, Institute of Biochemistry, Zhejiang Sci-Tech University, Hangzhou, China

Competing Interests

The investigational product ( BmrhGM-CSF capsule ) was donated by Zhejiang Chinagene Biopharmaceutical Co., Ltd. GGC, the director of R&D Department of Zhejiang Chinagene Biopharmaceutical Co., Ltd., supported this work. The other authors declare no competing interests exist.

Author Contributions

Conceived and designed the experiments: XW YZ. Analyzed the data: ZN JC QS. Wrote the paper: WZ ZL YJ. Supervised laboratory and clinical work: WZ ZL. Enrolled participants: GC WY.