Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling

Jin Nam; Baltazar D. Aguda; Bjoern Rath; Sudha Agarwal

doi:10.1371/journal.pone.0005262

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Open Access

Peer-reviewed

Research Article

Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling

Jin Nam,

Affiliation Biomechanics and Tissue Engineering Laboratory, College of Dentistry, The Ohio State University, Columbus, Ohio, United States of America
⨯
Baltazar D. Aguda,

Affiliations Mathematical Biosciences Institute, The Ohio State University, Columbus, Ohio, United States of America, Center for Critical Care, The Ohio State University Medical Center, Columbus, Ohio, United States of America
⨯
Bjoern Rath,

Affiliation Orthopaedic Surgery, University of Regensburg, Regensburg, Germany
⨯
Sudha Agarwal

* E-mail: agarwal.61@osu.edu

Affiliation Biomechanics and Tissue Engineering Laboratory, College of Dentistry, The Ohio State University, Columbus, Ohio, United States of America
⨯

Biomechanical Thresholds Regulate Inflammation through the NF-κB Pathway: Experiments and Modeling

Jin Nam,
Baltazar D. Aguda,
Bjoern Rath,
Sudha Agarwal

Published: April 16, 2009
https://doi.org/10.1371/journal.pone.0005262

About the Authors

Jin Nam

Affiliation Biomechanics and Tissue Engineering Laboratory, College of Dentistry, The Ohio State University, Columbus, Ohio, United States of America

Baltazar D. Aguda

Affiliations Mathematical Biosciences Institute, The Ohio State University, Columbus, Ohio, United States of America, Center for Critical Care, The Ohio State University Medical Center, Columbus, Ohio, United States of America

Bjoern Rath

Affiliation Orthopaedic Surgery, University of Regensburg, Regensburg, Germany

Sudha Agarwal

* E-mail: agarwal.61@osu.edu

Affiliation Biomechanics and Tissue Engineering Laboratory, College of Dentistry, The Ohio State University, Columbus, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JN BDA BR SA. Performed the experiments: JN BDA BR. Analyzed the data: JN BDA SA. Contributed reagents/materials/analysis tools: SA. Wrote the paper: JN BDA SA.

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Transcription factors
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Gene expression
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Inflammation
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Phosphorylation
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Biomechanics
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Cytokines
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Gene regulation
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Cartilage
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