About the Authors

Chao Zhang

Contributed equally to this work with: Chao Zhang, Na Yang

Affiliation Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Na Yang

Contributed equally to this work with: Chao Zhang, Na Yang

Affiliation Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Chun-hao Yang

Affiliation Division of Organic Synthesis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Hua-sheng Ding

Affiliation Division of Organic Synthesis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Cheng Luo

Affiliation Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Yu Zhang

Affiliation Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Mao-jiang Wu

Affiliation Division of Organic Synthesis, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Xiong-wen Zhang

Affiliation Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Xu Shen

Affiliations Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, School of Pharmacy, East China University of Science and Technology, Shanghai, China

Hua-liang Jiang

Affiliations Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, School of Pharmacy, East China University of Science and Technology, Shanghai, China

Ling-hua Meng

lhmeng@mail.shcnc.ac.cn (L-hM); jding@mail.shcnc.ac.cn (JD)

Affiliation Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Jian Ding

lhmeng@mail.shcnc.ac.cn (L-hM); jding@mail.shcnc.ac.cn (JD)

Affiliation Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LHM JD. Performed the experiments: CZ NY YZ. Analyzed the data: CZ NY LHM JD. Contributed reagents/materials/analysis tools: CY HsD MjW XWZ XS. Wrote the paper: CZ NY LHM JD. Molecular Modeling: CL HJ.