About the Authors

Verena Ilona Carrara

Affiliation Shoklo Malaria Research Unit, Tak, Thailand

Julien Zwang

Affiliation Shoklo Malaria Research Unit, Tak, Thailand

Elizabeth A. Ashley

Affiliations Shoklo Malaria Research Unit, Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Clinical Vaccinology and Tropical Medicine Churchill Hospital, Headington, Oxford, United Kingdom

Ric N. Price

Affiliations Centre for Clinical Vaccinology and Tropical Medicine Churchill Hospital, Headington, Oxford, United Kingdom, Menzies School of Health Research, Charles Darwin University, Darwin, Australia

Kasia Stepniewska

Affiliations Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Clinical Vaccinology and Tropical Medicine Churchill Hospital, Headington, Oxford, United Kingdom

Marion Barends

Affiliation Shoklo Malaria Research Unit, Tak, Thailand

Alan Brockman

Affiliation Menzies School of Health Research, Charles Darwin University, Darwin, Australia

Tim Anderson

Affiliation Southwest Foundation for Biomedical Research, San Antonio, Texas, United States of America

Rose McGready

Affiliations Shoklo Malaria Research Unit, Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Clinical Vaccinology and Tropical Medicine Churchill Hospital, Headington, Oxford, United Kingdom

Lucy Phaiphun

Affiliation Shoklo Malaria Research Unit, Tak, Thailand

Stephane Proux

Affiliation Shoklo Malaria Research Unit, Tak, Thailand

Michele van Vugt

Affiliation Shoklo Malaria Research Unit, Tak, Thailand

Robert Hutagalung

Affiliation Shoklo Malaria Research Unit, Tak, Thailand

Khin Maung Lwin

Affiliation Shoklo Malaria Research Unit, Tak, Thailand

Aung Pyae Phyo

Affiliation Shoklo Malaria Research Unit, Tak, Thailand

Piyanuch Preechapornkul

Affiliation Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Mallika Imwong

Affiliation Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Sasithon Pukrittayakamee

Affiliation Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Pratap Singhasivanon

Affiliation Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Nicholas J. White

Affiliations Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Clinical Vaccinology and Tropical Medicine Churchill Hospital, Headington, Oxford, United Kingdom

François Nosten

smru@tropmedres.ac

Affiliations Shoklo Malaria Research Unit, Tak, Thailand, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Clinical Vaccinology and Tropical Medicine Churchill Hospital, Headington, Oxford, United Kingdom

Competing Interests

N.J. White is co-chairman of the World Health Organization malaria treatment guidelines committee and is on the editorial board of PloS Medicine. The authors have no other conflict of interest to declare.

Author Contributions

Conceived and designed the experiments: PS NJW FN. Performed the experiments: EAA RNP MB AB RM LP MvV RH KML APP. Analyzed the data: VIC JZ EAA RNP KS MB AB TA RM SP MvV RH KML APP PP MI SP FN. Contributed reagents/materials/analysis tools: VIC JZ EAA RNP KS MB AB TA RM LP SP MvV RH KML APP PP MI SP PS NJW FN. Wrote the paper: VIC JZ EAA RNP KS MB AB TA RM LP SP MvV RH KML APP PP MI SP PS NJW FN. Compiled the individual studies: VIC. Analysed the clinical and parasitological response: VIC. Drafted the manuscript: VIC. Provided support to the statistical analysis: JZ KS. Supervised and analysed the in vivo studies: EAA RP RM MvV RH KML APP. Did the molecular analysis: RP TA PP MI SP. Coordinated and analysed the in vitro studies: MB AB. Coordinated the in vivo studies: LP. Supervised and controlled the quality of all laboratory results: SP. Supervised the research program: PS NJW.