About the Authors

J. R. Managbanag

Affiliation Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America

Tarynn M. Witten

tmwitten@vcu.edu (TMW); kaeber@u.washington.edu (MK)

Affiliation Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America

Danail Bonchev

Affiliations Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America, Department of Mathematics and Applied Mathematics, Virginia Commonwealth University, Richmond, Virginia, United States of America

Lindsay A. Fox

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Mitsuhiro Tsuchiya

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Brian K. Kennedy

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Matt Kaeberlein

tmwitten@vcu.edu (TMW); kaeber@u.washington.edu (MK)

Affiliation Department of Pathology, University of Washington, Seattle, Washington, United States of America

Competing Interests

MK and BK have a patent pending on the high-throughput method for analysis of replicative life span in yeast used in this study and previously described in published literature.

Author Contributions

Conceived and designed the experiments: JRM TMW DB MK. Performed the experiments: JRM LAF MT MK. Analyzed the data: JRM DB BKK MK. Contributed reagents/materials/analysis tools: TMW BKK MK. Wrote the paper: MK.