About the Authors
- Anna Kanerva
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Affiliations Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, Department of Obstetrics and Gynecology, Helsinki University Central Hospital (HUCH), Helsinki, Finland
- Sergio Lavilla-Alonso
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Affiliations Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, Transplantation Laboratory, HUSLAB, Helsinki University Central Hospital (HUCH), Helsinki, Finland
- Mari Raki
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Affiliations Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, Transplantation Laboratory, HUSLAB, Helsinki University Central Hospital (HUCH), Helsinki, Finland
- Lotta Kangasniemi
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Affiliations Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, Transplantation Laboratory, HUSLAB, Helsinki University Central Hospital (HUCH), Helsinki, Finland
- Gerd J. Bauerschmitz
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Affiliations Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, Transplantation Laboratory, HUSLAB, Helsinki University Central Hospital (HUCH), Helsinki, Finland, Department of Obstetrics and Gynecology, Heinrich-Heine University, Duesseldorf, Germany
- Koichi Takayama
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Affiliation Research Institute for Diseases of the Chest, Kyushu University, Fukuoka, Japan
- Ari Ristimäki
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Affiliation Department of Pathology, HUSLAB, Helsinki University Central Hospital (HUCH), and Genome-Scale Biology Program, University of Helsinki, Helsinki, Finland
- Renee A. Desmond
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Affiliation Comprehensive Cancer Center, Biostatistics and Bioinformatics Unit, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
- Akseli Hemminki
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* E-mail: akseli.hemminki@helsinki.fi
Affiliations Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, Transplantation Laboratory, HUSLAB, Helsinki University Central Hospital (HUCH), Helsinki, Finland
Competing Interests
The authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: AK KT AR AH. Performed the experiments: AK SLA MR LK GJB KT AR. Analyzed the data: AK SLA MR LK GJB KT AR RAD AH. Contributed reagents/materials/analysis tools: AK AH. Wrote the paper: AK AH. Analyzed the effect of anti-inflammatory reagents on transduction efficacy and the effect of dexamethasone on replication in vivo: SL. Analyzed the effect of anti-inflammatory reagents on oncolysis in vitro: MR. Helped with the in vivo experiment analyzing the effect of dexamethasone on therapeutic efficacy: MR. Evaluated the effect of dexamethasone on replication in vitro: MR. Assisted with in vivo experiments: LK. Analyzed the infectivity of human cervical cancer cell lines in vitro with capsid modified viruses: GB. Analyzed the biostatistics: RD. Analyzed histopathology in animal experiments: AR. Cloned and provided the VEGF-viruses: KT. Assisted in making plans: KT. Main researcher: AK. Performed most of the experiments with the help and assistance of other people: AK. Provided partial funding for the project: AK. Wrote most of the manuscript: AK. Supervisor: AH. Gave ideas: AH. Made plans: AH. Organized most funding for the project: AH. Contributed to the manuscript: SL MR LK RD AR GB KT AH.