About the Authors

Anna Kanerva

Affiliations Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, Department of Obstetrics and Gynecology, Helsinki University Central Hospital (HUCH), Helsinki, Finland

Sergio Lavilla-Alonso

Affiliations Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, Transplantation Laboratory, HUSLAB, Helsinki University Central Hospital (HUCH), Helsinki, Finland

Mari Raki

Affiliations Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, Transplantation Laboratory, HUSLAB, Helsinki University Central Hospital (HUCH), Helsinki, Finland

Lotta Kangasniemi

Affiliations Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, Transplantation Laboratory, HUSLAB, Helsinki University Central Hospital (HUCH), Helsinki, Finland

Gerd J. Bauerschmitz

Affiliations Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, Transplantation Laboratory, HUSLAB, Helsinki University Central Hospital (HUCH), Helsinki, Finland, Department of Obstetrics and Gynecology, Heinrich-Heine University, Duesseldorf, Germany

Koichi Takayama

Affiliation Research Institute for Diseases of the Chest, Kyushu University, Fukuoka, Japan

Ari Ristimäki

Affiliation Department of Pathology, HUSLAB, Helsinki University Central Hospital (HUCH), and Genome-Scale Biology Program, University of Helsinki, Helsinki, Finland

Renee A. Desmond

Affiliation Comprehensive Cancer Center, Biostatistics and Bioinformatics Unit, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Akseli Hemminki

akseli.hemminki@helsinki.fi

Affiliations Cancer Gene Therapy Group, Molecular Cancer Biology Program and Transplantation Laboratory and Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland, Transplantation Laboratory, HUSLAB, Helsinki University Central Hospital (HUCH), Helsinki, Finland

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AK KT AR AH. Performed the experiments: AK SLA MR LK GJB KT AR. Analyzed the data: AK SLA MR LK GJB KT AR RAD AH. Contributed reagents/materials/analysis tools: AK AH. Wrote the paper: AK AH. Analyzed the effect of anti-inflammatory reagents on transduction efficacy and the effect of dexamethasone on replication in vivo: SL. Analyzed the effect of anti-inflammatory reagents on oncolysis in vitro: MR. Helped with the in vivo experiment analyzing the effect of dexamethasone on therapeutic efficacy: MR. Evaluated the effect of dexamethasone on replication in vitro: MR. Assisted with in vivo experiments: LK. Analyzed the infectivity of human cervical cancer cell lines in vitro with capsid modified viruses: GB. Analyzed the biostatistics: RD. Analyzed histopathology in animal experiments: AR. Cloned and provided the VEGF-viruses: KT. Assisted in making plans: KT. Main researcher: AK. Performed most of the experiments with the help and assistance of other people: AK. Provided partial funding for the project: AK. Wrote most of the manuscript: AK. Supervisor: AH. Gave ideas: AH. Made plans: AH. Organized most funding for the project: AH. Contributed to the manuscript: SL MR LK RD AR GB KT AH.