About the Authors

Bu-Er Wang

Affiliation Department of Molecular Biology, Genentech, Inc., South San Francisco, California, United States of America

Xi-De Wang

Current address: Clinical Discovery, Bristol-Myers Squibb, Princeton, New Jersey, United States of America

Affiliation Department of Molecular Biology, Genentech, Inc., South San Francisco, California, United States of America

James A. Ernst

Affiliation Department of Protein Chemistry and Protein Engineering, Genentech, Inc., South San Francisco, California, United States of America

Paul Polakis

Affiliation Department of Cancer Target and Pathways, Genentech, Inc., South San Francisco, California, United States of America

Wei-Qiang Gao

gao@gene.com

Affiliation Department of Molecular Biology, Genentech, Inc., South San Francisco, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WG BW XW. Performed the experiments: BW. Analyzed the data: WG BW XW PP. Contributed reagents/materials/analysis tools: JE. Wrote the paper: WG BW XW. Other: Supervised the entire project: WG. Provided important input and suggestions: PP.