The Gammaherpesvirus m2 Protein Manipulates the Fyn/Vav Pathway through a Multidocking Mechanism of Assembly

Marta Pires de Miranda; Marta Alenquer; Sofia Marques; Lénia Rodrigues; Filipa Lopes; Xosé R. Bustelo; J. Pedro Simas

doi:10.1371/journal.pone.0001654

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Research Article

The Gammaherpesvirus m2 Protein Manipulates the Fyn/Vav Pathway through a Multidocking Mechanism of Assembly

Marta Pires de Miranda ,

Contributed equally to this work with: Marta Pires de Miranda, Marta Alenquer

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Marta Alenquer ,

Contributed equally to this work with: Marta Pires de Miranda, Marta Alenquer

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Sofia Marques,

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Lénia Rodrigues,

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Filipa Lopes,

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯
Xosé R. Bustelo ,

*E-mail: xbustelo@usal.es (XB); psimas@fm.ul.pt (JS)

Affiliation Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC), University of Salamanca, Salamanca, Spain
⨯
J. Pedro Simas

*E-mail: xbustelo@usal.es (XB); psimas@fm.ul.pt (JS)

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal
⨯

The Gammaherpesvirus m2 Protein Manipulates the Fyn/Vav Pathway through a Multidocking Mechanism of Assembly

Marta Pires de Miranda,
Marta Alenquer,
Sofia Marques,
Lénia Rodrigues,
Filipa Lopes,
Xosé R. Bustelo,
J. Pedro Simas

Published: February 27, 2008
https://doi.org/10.1371/journal.pone.0001654

About the Authors

Marta Pires de Miranda

Contributed equally to this work with: Marta Pires de Miranda, Marta Alenquer

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

Marta Alenquer

Contributed equally to this work with: Marta Pires de Miranda, Marta Alenquer

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

Sofia Marques

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

Lénia Rodrigues

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

Filipa Lopes

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

Xosé R. Bustelo

*E-mail: xbustelo@usal.es (XB); psimas@fm.ul.pt (JS)

Affiliation Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer, Consejo Superior de Investigaciones Científicas (CSIC), University of Salamanca, Salamanca, Spain

J. Pedro Simas

*E-mail: xbustelo@usal.es (XB); psimas@fm.ul.pt (JS)

Affiliations Instituto de Microbiologia e Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Instituto Gulbenkian de Ciência, Oeiras, Portugal

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XB JS MP MA SM. Performed the experiments: MP MA LR. Analyzed the data: XB JS MP MA SM. Contributed reagents/materials/analysis tools: MP MA SM LR FL. Wrote the paper: XB JS.

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Phosphorylation
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B cells
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Immunoprecipitation
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Viral persistence and latency
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Tyrosine
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SH2 domains
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Spleen
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Herpesviruses
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