Endothelial Domes Encapsulate Adherent Neutrophils and Minimize Increases in Vascular Permeability in Paracellular and Transcellular Emigration

Mia Phillipson; Jaswinder Kaur; Pina Colarusso; Christie M. Ballantyne; Paul Kubes

doi:10.1371/journal.pone.0001649

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Open Access

Peer-reviewed

Research Article

Endothelial Domes Encapsulate Adherent Neutrophils and Minimize Increases in Vascular Permeability in Paracellular and Transcellular Emigration

Mia Phillipson,

Affiliation Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
⨯
Jaswinder Kaur,

Affiliation Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
⨯
Pina Colarusso,

Affiliation Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
⨯
Christie M. Ballantyne,

Affiliation Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center and Baylor College of Medicine, Houston, Texas, United States of America
⨯
Paul Kubes

*E-mail: pkubes@ucalgary.ca

Affiliation Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
⨯

Endothelial Domes Encapsulate Adherent Neutrophils and Minimize Increases in Vascular Permeability in Paracellular and Transcellular Emigration

Mia Phillipson,
Jaswinder Kaur,
Pina Colarusso,
Christie M. Ballantyne,
Paul Kubes

Published: February 20, 2008
https://doi.org/10.1371/journal.pone.0001649

About the Authors

Mia Phillipson

Affiliation Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

Jaswinder Kaur

Affiliation Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada

Pina Colarusso

Affiliation Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada

Christie M. Ballantyne

Affiliation Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center and Baylor College of Medicine, Houston, Texas, United States of America

Paul Kubes

*E-mail: pkubes@ucalgary.ca

Affiliation Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PK MP JK PC. Performed the experiments: MP JK PC. Analyzed the data: MP. Contributed reagents/materials/analysis tools: PK CB. Wrote the paper: MP.

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Neutrophils
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Vascular permeability
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Endothelium
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White blood cells
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Endothelial cells
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Confocal microscopy
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Lymphocytes
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Venules
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