Mammalian MicroRNA Prediction through a Support Vector Machine Model of Sequence and Structure

Ying Sheng; Pär G. Engström; Boris Lenhard

doi:10.1371/journal.pone.0000946

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Open Access

Peer-reviewed

Research Article

Mammalian MicroRNA Prediction through a Support Vector Machine Model of Sequence and Structure

Ying Sheng,

Affiliations Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, Bergen, Norway, Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway, Programme for Genomics and Bioinformatics, Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
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Pär G. Engström,

Affiliations Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, Bergen, Norway, Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway, Programme for Genomics and Bioinformatics, Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
⨯
Boris Lenhard

*To whom correspondence should be addressed. E-mail: Boris.Lenhard@bccs.uib.no

Affiliations Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, Bergen, Norway, Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway
⨯

Mammalian MicroRNA Prediction through a Support Vector Machine Model of Sequence and Structure

Ying Sheng,
Pär G. Engström,
Boris Lenhard

Published: September 26, 2007
https://doi.org/10.1371/journal.pone.0000946

About the Authors

Ying Sheng

Affiliations Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, Bergen, Norway, Sars International Centre for Marine Molecular Biology, University of Bergen, Bergen, Norway, Programme for Genomics and Bioinformatics, Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden

Pär G. Engström

Boris Lenhard

*To whom correspondence should be addressed. E-mail: Boris.Lenhard@bccs.uib.no

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BL. Performed the experiments: PE YS. Analyzed the data: PE YS. Wrote the paper: PE BL YS.

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MicroRNAs
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Mammalian genomics
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Human genomics
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RNA stem-loop structure
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Sequence alignment
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RNA structure
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Free energy
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Cloning
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