Loss of Robustness and Addiction to IGF1 during Early Keratinocyte Transformation by Human Papilloma Virus 16

Tamar Geiger; Alexander Levitzki

doi:10.1371/journal.pone.0000605

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Open Access

Peer-reviewed

Research Article

Loss of Robustness and Addiction to IGF1 during Early Keratinocyte Transformation by Human Papilloma Virus 16

Tamar Geiger,

Affiliation Unit of Cellular Signaling, Department of Biological Chemistry, The Alexander Silverman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
⨯
Alexander Levitzki

*To whom correspondence should be addressed. E-mail: levitzki@vms.huji.ac.il

Affiliation Unit of Cellular Signaling, Department of Biological Chemistry, The Alexander Silverman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
⨯

Loss of Robustness and Addiction to IGF1 during Early Keratinocyte Transformation by Human Papilloma Virus 16

Tamar Geiger,
Alexander Levitzki

Published: July 11, 2007
https://doi.org/10.1371/journal.pone.0000605

About the Authors

Tamar Geiger

Affiliation Unit of Cellular Signaling, Department of Biological Chemistry, The Alexander Silverman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

Alexander Levitzki

*To whom correspondence should be addressed. E-mail: levitzki@vms.huji.ac.il

Affiliation Unit of Cellular Signaling, Department of Biological Chemistry, The Alexander Silverman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AL TG. Performed the experiments: TG. Analyzed the data: TG. Wrote the paper: AL TG.

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Keratinocytes
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Apoptosis
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HPV-16
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Transfection
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Cellular stress responses
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Phosphorylation
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Stress signaling cascade
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Cell immortalization
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