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NF-KB as a master regulator - evidence lacking

Posted by winhide on 19 Sep 2008 at 18:48 GMT

The claim that NF-KB has been identified as a 'master regulator" should be supported by proper evidence. The presence of a binding site in the promotors of genes of interest, by itself, is insufficient evidence, because of the ubiquity of these binding sites across the genome. Without biological support, this claim is not supported and should be removed.