Investigation into the Presence of and Serological Response to XMRV in CFS Patients

Otto Erlwein; Mark J. Robinson; Steve Kaye; Gillian Wills; Shozo Izui; Simon Wessely; Jonathan Weber; Anthony Cleare; David Collier; Myra O. McClure

doi:10.1371/journal.pone.0017592

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Peer-reviewed

Research Article

Investigation into the Presence of and Serological Response to XMRV in CFS Patients

Otto Erlwein,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Mark J. Robinson,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Steve Kaye,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Gillian Wills,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Shozo Izui,

Affiliation Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
⨯
Simon Wessely,

Affiliation Department of Psychological Medicine, Institute of Psychiatry, King's College London, Camberwell, London, United Kingdom
⨯
Jonathan Weber,

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯
Anthony Cleare,

Affiliation Department of Psychological Medicine, Institute of Psychiatry, King's College London, Camberwell, London, United Kingdom
⨯
David Collier,

Affiliation Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United Kingdom
⨯
Myra O. McClure

* E-mail: m.mcclure@imperial.ac.uk

Affiliation Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
⨯

Investigation into the Presence of and Serological Response to XMRV in CFS Patients

Otto Erlwein,
Mark J. Robinson,
Steve Kaye,
Gillian Wills,
Shozo Izui,
Simon Wessely,
Jonathan Weber,
Anthony Cleare,
David Collier,
Myra O. McClure

Published: March 9, 2011
https://doi.org/10.1371/journal.pone.0017592

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Alternative Interpretation of Results & Conclusions

Posted by HERVK102-proponent on 17 Mar 2011 at 14:15 GMT

If we take 2.5 X background of the BSA background, about 52% of CFS and 27% of NHS may have been positive by serology. Based on 3c, similarly about 80% CFS and 23% NHS would be positive. Specificity is determined by western blotting and antigen sequencing, respectively, not arguments. Plasmids are not useful as controls & needed a positive WB sample for the PCR.

No competing interests declared.

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Investigation into the Presence of and Serological Response to XMRV in CFS Patients

Investigation into the Presence of and Serological Response to XMRV in CFS Patients

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Alternative Interpretation of Results & Conclusions

Posted by HERVK102-proponent on 17 Mar 2011 at 14:15 GMT