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Research Article

Identifying Selected Regions from Heterozygosity and Divergence Using a Light-Coverage Genomic Dataset from Two Human Populations

  • Taras K. Oleksyk mail,

    *E-mail: oleksyk@ncifcrf.gov

    Affiliations: Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Kai Zhao,

    Affiliation: Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Francisco M. De La Vega,

    Affiliation: Applied Biosystems, Foster City, California, United States of America

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  • Dennis A. Gilbert,

    Affiliation: Applied Biosystems, Foster City, California, United States of America

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  • Stephen J. O'Brien,

    Affiliation: Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Michael W. Smith

    Affiliations: Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, Maryland, United States of America, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland, United States of America

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  • Published: March 05, 2008
  • DOI: 10.1371/journal.pone.0001712

Reader Comments (16)

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Siganture age for CCR5

Posted by oleksyk on 20 Mar 2008 at 16:14 GMT

An “old” selection event
http://plosone.org/article/info:doi/10.1371/journal.pone.0001712#article1.body1.sec2.sec3.p1

This selection signature is likely to be older then the date of separation between African and European populations. Other studies implicated CCR5 as a target of much more recent selection (<1000 years).