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Research Article

Serial Killing of Tumor Cells by Human Natural Killer Cells – Enhancement by Therapeutic Antibodies

  • Rauf Bhat,

    Affiliation: Institute for Immunology, University Heidelberg, Heidelberg, Germany

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  • Carsten Watzl mail

    To whom correspondence should be addressed. E-mail: Carsten.watzl@urz.uni-heidelberg.de

    Affiliation: Institute for Immunology, University Heidelberg, Heidelberg, Germany

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  • Published: March 28, 2007
  • DOI: 10.1371/journal.pone.0000326

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missing references

Posted by CWatzl on 31 May 2007 at 10:57 GMT

Previous reports have attempted to unravel the killing frequency of mouse CTLs under controlled conditions and observed that a single CTL can eliminate up to six targets [3]
http://plosone.org/article/info:doi/10.1371/journal.pone.0000326#article1.body1.sec3.p1

Unfortunately, we did not cite the original work that actually showed serial killing by CTL. Here are the references which should have been included:

Berke, G., Sullivan, K.A. and Amos, D.B. (1972). Tumor immunity in vitro: Destruction of a mouse ascites tumor through a cycling pathway. Science, 177: 433-434.

Zagury, D., Bernard, J., Thierness, N., Feldman, M. and Berke, G. (1975). Isolation and characterization of individual functionally reactive cytotoxic T lymphocytes. Conjugation, killing and recycling at the single cell level. Eur. J. Immunol., 5: 818-822.