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Research Article

Functional Significance of Allelic Variation at methuselah, an Aging Gene in Drosophila

  • Annalise B. Paaby mail,

    paaby@sas.upenn.edu

    Affiliation: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Paul S. Schmidt

    Affiliation: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

    X
  • Published: April 16, 2008
  • DOI: 10.1371/journal.pone.0001987

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Kim Hughes' evaluation of this article at the Faculty of 1000 Biology

Posted by NiyazAhmed on 29 Jun 2008 at 08:50 GMT

Kim Hughes (University of Illinois at Urbana-Champaign, United States of America) has commented on this article at the Faculty of 1000 Biology. Her/his comments are as under:

"This paper describes the first evidence that one of the well-known candidate “aging” genes (methuselah) is functionally relevant to lifespan variation in nature. Quantitative complementation tests show that alleles derived from different natural populations differ in their effects on lifespan, oxidative stress resistance, and fecundity, and the natural alleles often have sex-specific effects. Consistent with other studies, lifespan and stress resistance effects are positively correlated. Somewhat surprisingly, mth mutants did not have generally elevated lifespan, although one of two mutants did show elevated oxidative stress resistance and elevated fecundity compared to a wild type allele".

Reference:

1) Kim Hughes: Faculty of 1000 Biology, 1 May 2008 http://www.f1000biology.c...

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Section Editor, PLoS ONE
Faculty Member, F1000Biology and F1000Medicine
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