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Research Article

Canine Population Structure: Assessment and Impact of Intra-Breed Stratification on SNP-Based Association Studies

  • Pascale Quignon,

    Affiliation: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Laetitia Herbin,

    Affiliation: CNRS UMR6061 Génétique et Développement, Université de Rennes 1, IFR140, CS 34317, Rennes, France

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  • Edouard Cadieu,

    Affiliation: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ewen F. Kirkness,

    Affiliation: The J Craig Venter Institute, Rockville, Maryland, United States of America

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  • Benoit Hédan,

    Affiliation: CNRS UMR6061 Génétique et Développement, Université de Rennes 1, IFR140, CS 34317, Rennes, France

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  • Dana S. Mosher,

    Affiliation: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Francis Galibert,

    Affiliation: CNRS UMR6061 Génétique et Développement, Université de Rennes 1, IFR140, CS 34317, Rennes, France

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  • Catherine André,

    Affiliation: CNRS UMR6061 Génétique et Développement, Université de Rennes 1, IFR140, CS 34317, Rennes, France

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  • Elaine A. Ostrander mail,

    To whom correspondence should be addressed. E-mail: eostrand@mail.nih.gov (EO); hitte@univ-rennes1.fr (CH)

    Affiliation: Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Christophe Hitte mail

    To whom correspondence should be addressed. E-mail: eostrand@mail.nih.gov (EO); hitte@univ-rennes1.fr (CH)

    Affiliation: CNRS UMR6061 Génétique et Développement, Université de Rennes 1, IFR140, CS 34317, Rennes, France

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  • Published: December 19, 2007
  • DOI: 10.1371/journal.pone.0001324

Reader Comments (2)

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Why would this be?

Posted by asolove on 21 Dec 2007 at 00:58 GMT

one GR remaining as an outlier
http://plosone.org/article/info:doi/10.1371/journal.pone.0001324#article1.body1.sec2.sec6.p1

I'm certain the authors can explain, but I would like to know why.