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Research Article

The Tricarboxylic Acid Cycle, an Ancient Metabolic Network with a Novel Twist

  • Ryan J. Mailloux,

    Affiliation: Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada

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  • Robin Bériault,

    Affiliation: Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada

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  • Joseph Lemire,

    Affiliation: Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada

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  • Ranji Singh,

    Affiliation: Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada

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  • Daniel R. Chénier,

    Affiliation: Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada

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  • Robert D. Hamel,

    Affiliation: Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada

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  • Vasu D. Appanna mail

    To whom correspondence should be addressed. E-mail: VAppanna@laurentian.ca

    Affiliation: Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada

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  • Published: August 01, 2007
  • DOI: 10.1371/journal.pone.0000690

Reader Comments (1)

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Referee Comments: Referee 1

Posted by PLoS_ONE_Group on 09 Aug 2007 at 23:15 GMT


Reviewer 1's Review (Pierre Cornelis)

I have been through the rather extensive report of Mailloux et al."The Tricarboxylic acid cycle, an ancient metabolic network with a novel twist." and I found it very well written and well documented.

The results are convincing and the conclusion quite important because it changes our view of the TCA cycle and shows that it can be modulated by oxydative stress. I have been aware of previous publications of the group and this one is probably the best. I really enjoyed reading this beautiful manuscript.

N.B. These are the general comments made by the reviewer when reviewing this paper. Specific points addressed during revision of the paper are not shown.