The study can be reproduced without problem. The knowledge of classical homeopathy, will help to deeply understand many aspects of the article and give an objective and unbiased opinion.

The homeopathic medicines were provided by Laboratorio Similia in Mexico City. It is a prestigious laboratory that produces homeopathic medicines according to a standardized method in compliance with COFEPRIS regulation. COFEPRIS is the institution in charge of the regulation of the production of medicines in Mexico (like FDA in USA). In the Methods section, there is a description of how C-potencies are prepared, so it could be clear, but nowadays the homeopathic medicines are not handmade. They are not magic or witchcraft. All the homeopathic medicines used in the study were provided by the laboratory mentioned above according to standardized and well established guidelines. Moreover, the homeopathic medicines used in the study are available for everybody.

The study aimed to evaluate the efficacy of the individualized homeopathic treatment as a whole, an individualized prescription means selecting an individualized remedy according to the patient's symptoms in the appropriate potency needed to heal. That is classical homeopathy. In general terms, homeopathy studies the patient as a whole, taking into account that is a human being that might be physically and mentally ill. This is not magic, is a comprehensive medical approach or holistic care. The study did not aim to evaluate the same medicine for all patients. As the selection and prescription in homeopathy is individualized, the same prescription for all patients will surely fail in improving depressive symptoms. Again, this is not magic, it is the methodology of the classical homeopathic prescription.

Furthermore, there is also a description of how the homeopathic medicines were chosen for each individual prescription according to the classical homeopathy. The way the homeopathic doctor prescribes the medicine includes the same routine clinical examination plus many other facts. The paper describes it as follows: "a full homeopathic case-taking including the collection of all the facts pertaining to the patient which may help in reaching the totality of the symptoms: past and present physical and emotional symptoms, family environment since childhood, stressful life events, marital satisfaction. The symptoms were organized by hierarchy: mental, general and physical. In first place, the strategy to choose the individualized remedy was based on the most characteristic and clear mental symptoms. Secondly, general symptoms were taken into account. Computerized version of Synthesis Homeopathic Repertory 9.1 (Radar version 10) was used to facilitate the prescription. Only one remedy was prescribed at a time but it could be changed at every follow-up according to patient's symptoms".