A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Jamie L. Barger; Tsuyoshi Kayo; James M. Vann; Edward B. Arias; Jelai Wang; Timothy A. Hacker; Ying Wang; Daniel Raederstorff; Jason D. Morrow; Christiaan Leeuwenburgh; David B. Allison; Kurt W. Saupe; Gregory D. Cartee; Richard Weindruch; Tomas A. Prolla

doi:10.1371/journal.pone.0002264

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Research Article

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Jamie L. Barger,

Affiliation LifeGen Technologies, LLC, Madison, Wisconsin, United States of America
⨯
Tsuyoshi Kayo,

Affiliation LifeGen Technologies, LLC, Madison, Wisconsin, United States of America
⨯
James M. Vann,

Affiliations Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America
⨯
Edward B. Arias,

Affiliation Division of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Jelai Wang,

Affiliation Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Timothy A. Hacker,

Affiliation Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Ying Wang,

Affiliation R&D Human Nutrition and Health, DSM Nutritional Products Ltd., Basel, Switzerland
⨯
Daniel Raederstorff,

Affiliation R&D Human Nutrition and Health, DSM Nutritional Products Ltd., Basel, Switzerland
⨯
Jason D. Morrow,

Affiliations Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Christiaan Leeuwenburgh,

Affiliation Department of Aging and Geriatrics and College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
David B. Allison,

Affiliation Section on Statistical Genetics, Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Kurt W. Saupe,

Affiliation Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Gregory D. Cartee,

Affiliation Division of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Richard Weindruch ,

* E-mail: rhweindr@wisc.edu (RW); taprolla@wisc.edu (TP)

Affiliation Department of Medicine and Veterans Administration Hospital, University of Wisconsin-Madison, Madison, Wisconsin, United States of America
⨯
Tomas A. Prolla

* E-mail: rhweindr@wisc.edu (RW); taprolla@wisc.edu (TP)

Affiliations Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America
⨯

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Jamie L. Barger,
Tsuyoshi Kayo,
James M. Vann,
Edward B. Arias,
Jelai Wang,
Timothy A. Hacker,
Ying Wang,
Daniel Raederstorff,
Jason D. Morrow,
Christiaan Leeuwenburgh

Published: June 4, 2008
https://doi.org/10.1371/journal.pone.0002264

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Not all mice, and persons, are created equal!

Posted by Stagnaro on 09 Jun 2008 at 12:22 GMT

A part from the fact that such as research has been conducted in mice, the Authors seem to ignore the existence of Biophyisical-Semeiotic Constitutions, and related Inherited Real Risk, Single Patient Based Medicine is based on (1-5).
As a consequence, if individuals showing to have a physiological natural defence system against free radicals (Resveratrol acts principally as anti free-radicals), evaluated at the bedside (6-8) and moreover they are not involved by diabetic, hypertensive, arteriosclerotic constitutions as well as oncological terrain, and they smokes a large number of sigarettes every day, without drinking red wine, may we conclude that tobacco smoking is beneficial against cancer, diabetes, arteriosclerosis, and hypertension!

1. Stagnaro-Neri M., Stagnaro S. Sindrome di Reaven, classica e variante, in evoluzione diabetica. Il ruolo della Carnitina nella prevenzione del diabete mellito. Il Cuore. 6, 617, 1993 [ MEDLINE]
2. Stagnaro-Neri M, Stagnaro S. Co Q10 in the prevention and treatment of primary osteoporosis. Preliminary data. Clin Ter. 1995 Mar;146(3):215-9 [ MEDLINE]
3. Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ediz. Travel Factory, Roma, 2004. http://www.travelfactory....
4. Stagnaro Sergio, Stagnaro-Neri Marina. Introduzione alla Semeiotica Biofisica. Il Terreno oncologico”. Travel Factory SRL., Roma, 2004. . http://www.travelfactory....
5. Stagnaro S., Stagnaro-Neri M., Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory SRL., Roma, 2005. http://www.travelfactory....
6) Stagnaro Sergio. Single Patient Based Medicine: its paramount role in Future Medicine. Public Library of Science.2005 http://medicine.plosjourn...
7) Stagnaro Sergio. Newborn-pathological Endoarteriolar Blocking Devices in Diabetic and Dislipidaemic Constitution and Diabetes Primary Prevention. The Lancet. March 06 2007. http://www.thelancet.com/...
8) Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning - c007i. Lecture, V Virtual International Congress of Cardiology. http://www.fac.org.ar/qcv...

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A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

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Not all mice, and persons, are created equal!

Posted by Stagnaro on 09 Jun 2008 at 12:22 GMT