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Research Article

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

  • Jamie L. Barger,

    Affiliation: LifeGen Technologies, LLC, Madison, Wisconsin, United States of America

    X
  • Tsuyoshi Kayo,

    Affiliation: LifeGen Technologies, LLC, Madison, Wisconsin, United States of America

    X
  • James M. Vann,

    Affiliations: Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America

    X
  • Edward B. Arias,

    Affiliation: Division of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Jelai Wang,

    Affiliation: Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Timothy A. Hacker,

    Affiliation: Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Ying Wang,

    Affiliation: R&D Human Nutrition and Health, DSM Nutritional Products Ltd., Basel, Switzerland

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  • Daniel Raederstorff,

    Affiliation: R&D Human Nutrition and Health, DSM Nutritional Products Ltd., Basel, Switzerland

    X
  • Jason D. Morrow,

    Affiliations: Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

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  • Christiaan Leeuwenburgh,

    Affiliation: Department of Aging and Geriatrics and College of Medicine, University of Florida, Gainesville, Florida, United States of America

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  • David B. Allison,

    Affiliation: Section on Statistical Genetics, Department of Biostatistics and Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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  • Kurt W. Saupe,

    Affiliation: Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

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  • Gregory D. Cartee,

    Affiliation: Division of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Richard Weindruch mail,

    rhweindr@wisc.edu (RW); taprolla@wisc.edu (TP)

    Affiliation: Department of Medicine and Veterans Administration Hospital, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

    X
  • Tomas A. Prolla mail

    rhweindr@wisc.edu (RW); taprolla@wisc.edu (TP)

    Affiliations: Department of Medical Genetics, University of Wisconsin, Madison, Wisconsin, United States of America, Department of Genetics, University of Wisconsin, Madison, Wisconsin, United States of America

    X
  • Published: June 04, 2008
  • DOI: 10.1371/journal.pone.0002264

Reader Comments (5)

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Not all mice, and persons, are created equal!

Posted by Stagnaro on 09 Jun 2008 at 12:22 GMT

A part from the fact that such as research has been conducted in mice, the Authors seem to ignore the existence of Biophyisical-Semeiotic Constitutions, and related Inherited Real Risk, Single Patient Based Medicine is based on (1-5).
As a consequence, if individuals showing to have a physiological natural defence system against free radicals (Resveratrol acts principally as anti free-radicals), evaluated at the bedside (6-8) and moreover they are not involved by diabetic, hypertensive, arteriosclerotic constitutions as well as oncological terrain, and they smokes a large number of sigarettes every day, without drinking red wine, may we conclude that tobacco smoking is beneficial against cancer, diabetes, arteriosclerosis, and hypertension!

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