Inhibition of Hedgehog Signaling Antagonizes Serous Ovarian Cancer Growth in a Primary Xenograft Model

Christopher K. McCann; Whitfield B. Growdon; Kashmira Kulkarni-Datar; Michael D. Curley; Anne M. Friel; Jennifer L. Proctor; Hana Sheikh; Igor Deyneko; Jeanne A. Ferguson; Vinod Vathipadiekal; Michael J. Birrer; Darrell R. Borger; Gayatry Mohapatra; Lawrence R. Zukerberg; Rosemary Foster; John R. MacDougall; Bo R. Rueda

doi:10.1371/journal.pone.0028077

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Inhibition of Hedgehog Signaling Antagonizes Serous Ovarian Cancer Growth in a Primary Xenograft Model

Christopher K. McCann,

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Gynecologic Oncology, Department of Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
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Whitfield B. Growdon,

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Gynecologic Oncology, Department of Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Kashmira Kulkarni-Datar,

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Michael D. Curley,

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Anne M. Friel,

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jennifer L. Proctor,

Affiliation Infinity Pharmaceuticals, Cambridge, Massachusetts, United States of America
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Hana Sheikh,

Affiliation Infinity Pharmaceuticals, Cambridge, Massachusetts, United States of America
⨯
Igor Deyneko,

Affiliation Infinity Pharmaceuticals, Cambridge, Massachusetts, United States of America
⨯
Jeanne A. Ferguson,

Affiliation Infinity Pharmaceuticals, Cambridge, Massachusetts, United States of America
⨯
Vinod Vathipadiekal,

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America
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Michael J. Birrer,

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America
⨯
Darrell R. Borger,

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America
⨯
Gayatry Mohapatra,

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Division of Hematology-Oncology, Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States of America
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Lawrence R. Zukerberg,

Affiliations Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
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Rosemary Foster,

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
John R. MacDougall,

Affiliation Infinity Pharmaceuticals, Cambridge, Massachusetts, United States of America
⨯
[ ... ],
Bo R. Rueda

* E-mail: brueda@partners.org

Affiliations Department of Vincent Obstetrics and Gynecology, Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Division of Gynecologic Oncology, Department of Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
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Inhibition of Hedgehog Signaling Antagonizes Serous Ovarian Cancer Growth in a Primary Xenograft Model

Christopher K. McCann,
Whitfield B. Growdon,
Kashmira Kulkarni-Datar,
Michael D. Curley,
Anne M. Friel,
Jennifer L. Proctor,
Hana Sheikh,
Igor Deyneko,
Jeanne A. Ferguson,
Vinod Vathipadiekal

Published: November 29, 2011
https://doi.org/10.1371/journal.pone.0028077

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Posted by PLOS_ONE_Group on 06 Apr 2012 at 18:33 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: Business Wire
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Competing interests declared: PLoS ONE Staff

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Ovarian cancer
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Hedgehog signaling
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Signal inhibition
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Inhibition of Hedgehog Signaling Antagonizes Serous Ovarian Cancer Growth in a Primary Xenograft Model

Inhibition of Hedgehog Signaling Antagonizes Serous Ovarian Cancer Growth in a Primary Xenograft Model

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 06 Apr 2012 at 18:33 GMT