Inhibition of Oxygen-Induced Ischemic Retinal Neovascularization with Adenoviral 15-Lipoxygenase-1 Gene Transfer via Up-Regulation of PPAR-γ and Down-Regulation of VEGFR-2 Expression

Zhi Li; Tao He; Ke Du; Yi-Qiao Xing; Yuan-Min Run; Ying Yan; Yin Shen

doi:10.1371/journal.pone.0085824

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Research Article

Inhibition of Oxygen-Induced Ischemic Retinal Neovascularization with Adenoviral 15-Lipoxygenase-1 Gene Transfer via Up-Regulation of PPAR-γ and Down-Regulation of VEGFR-2 Expression

Zhi Li ,

Contributed equally to this work with: Zhi Li, Tao He

Affiliations Eye Center, Renmin Hospital of Wuhan University, Eye Institute of Wuhan University, Wuhan, Hubei, China, Department of Ophthalmology, Hospital Affiliated to Hubei University of Arts and Science, Xiangyang Central Hospital, Xiangyang, Hubei, China
⨯
Tao He ,

Contributed equally to this work with: Zhi Li, Tao He

Affiliation Eye Center, Renmin Hospital of Wuhan University, Eye Institute of Wuhan University, Wuhan, Hubei, China
⨯
Ke Du,

Affiliation Department of Oncology, Hospital Affiliated to Hubei University of Arts and Science, Xiangyang Central Hospital, Xiangyang, Hubei, China
⨯
Yi-Qiao Xing ,

* E-mail: xyqdr@yahoo.com.cn (YQX); yinshen@whu.edu.cn (YS)

Affiliation Eye Center, Renmin Hospital of Wuhan University, Eye Institute of Wuhan University, Wuhan, Hubei, China
⨯
Yuan-Min Run,

Affiliation Clinical Laboratory, Hospital Affiliated to Hubei University of Arts and Science, Xiangyang Central Hospital, Xiangyang, Hubei, China
⨯
Ying Yan,

Affiliation Department of Ophthalmology, Wuhan General Hospital of Guangzhou Military, Wuhan, Hubei, China
⨯
Yin Shen

* E-mail: xyqdr@yahoo.com.cn (YQX); yinshen@whu.edu.cn (YS)

Affiliation Eye Center, Renmin Hospital of Wuhan University, Eye Institute of Wuhan University, Wuhan, Hubei, China
⨯

Inhibition of Oxygen-Induced Ischemic Retinal Neovascularization with Adenoviral 15-Lipoxygenase-1 Gene Transfer via Up-Regulation of PPAR-γ and Down-Regulation of VEGFR-2 Expression

Zhi Li,
Tao He,
Ke Du,
Yi-Qiao Xing,
Yuan-Min Run,
Ying Yan,
Yin Shen

Published: January 21, 2014
https://doi.org/10.1371/journal.pone.0085824

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In 2013 we published relationship of an exonic variant in PPARGC1A with neovascular AMD

Posted by jpsangio on 19 Jul 2014 at 17:07 GMT

In 2013 we published relationship of an exonic variant in PPARGC1A with neovascular AMD. We have put this in the context of the VEGFA system and VEGF receptors.

http://www.plosone.org/ar...

No competing interests declared.

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Inhibition of Oxygen-Induced Ischemic Retinal Neovascularization with Adenoviral 15-Lipoxygenase-1 Gene Transfer via Up-Regulation of PPAR-γ and Down-Regulation of VEGFR-2 Expression

Inhibition of Oxygen-Induced Ischemic Retinal Neovascularization with Adenoviral 15-Lipoxygenase-1 Gene Transfer via Up-Regulation of PPAR-γ and Down-Regulation of VEGFR-2 Expression

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In 2013 we published relationship of an exonic variant in PPARGC1A with neovascular AMD

Posted by jpsangio on 19 Jul 2014 at 17:07 GMT