Inhibition of PI3K/mTOR Overcomes Nilotinib Resistance in BCR-ABL1 Positive Leukemia Cells through Translational Down-Regulation of MDM2

Jie Ding; Julia Romani; Margarete Zaborski; Roderick A. F. MacLeod; Stefan Nagel; Hans G. Drexler; Hilmar Quentmeier

doi:10.1371/journal.pone.0083510

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Open Access

Peer-reviewed

Research Article

Inhibition of PI3K/mTOR Overcomes Nilotinib Resistance in BCR-ABL1 Positive Leukemia Cells through Translational Down-Regulation of MDM2

Jie Ding ,

* E-mail: jid12@dsmz.de

Affiliation Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Lines, Braunschweig, Germany
⨯
Julia Romani,

Affiliation Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Lines, Braunschweig, Germany
⨯
Margarete Zaborski,

Affiliation Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Lines, Braunschweig, Germany
⨯
Roderick A. F. MacLeod,

Affiliation Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Lines, Braunschweig, Germany
⨯
Stefan Nagel,

Affiliation Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Lines, Braunschweig, Germany
⨯
Hans G. Drexler,

Affiliation Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Lines, Braunschweig, Germany
⨯
Hilmar Quentmeier

Affiliation Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Department of Human and Animal Cell Lines, Braunschweig, Germany
⨯

Inhibition of PI3K/mTOR Overcomes Nilotinib Resistance in BCR-ABL1 Positive Leukemia Cells through Translational Down-Regulation of MDM2

Jie Ding,
Julia Romani,
Margarete Zaborski,
Roderick A. F. MacLeod,
Stefan Nagel,
Hans G. Drexler,
Hilmar Quentmeier

Published: December 11, 2013
https://doi.org/10.1371/journal.pone.0083510

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Change of corresponding email address

Posted by Plosreaders on 05 Jun 2014 at 09:44 GMT

My name is Jie Ding. I am the corresponding author of this paper. Because of the job change, the new corresponding email address will be djxjy641@gmail.com. Thank you.

Best,

Jie Ding

No competing interests declared.

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Inhibition of PI3K/mTOR Overcomes Nilotinib Resistance in BCR-ABL1 Positive Leukemia Cells through Translational Down-Regulation of MDM2

Inhibition of PI3K/mTOR Overcomes Nilotinib Resistance in BCR-ABL1 Positive Leukemia Cells through Translational Down-Regulation of MDM2

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Change of corresponding email address

Posted by Plosreaders on 05 Jun 2014 at 09:44 GMT