Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry

Qimei He; Brian J. Morris; John S. Grove; Helen Petrovitch; Webster Ross; Kamal H. Masaki; Beatriz Rodriguez; Randi Chen; Timothy A. Donlon; D. Craig Willcox; Bradley J. Willcox

doi:10.1371/journal.pone.0094385

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Research Article

Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry

Qimei He,

Affiliations Honolulu Heart Program/Honolulu-Asia Aging Study, Physicians’ Office Tower, Kuakini Medical Center, Honolulu, Hawaii, United States of America, Pacific Health Research and Education Institute of the Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii, Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America
⨯
Brian J. Morris ,

* E-mail: brian.morris@sydney.edu.au

Affiliations Honolulu Heart Program/Honolulu-Asia Aging Study, Physicians’ Office Tower, Kuakini Medical Center, Honolulu, Hawaii, United States of America, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia
⨯
John S. Grove,

Affiliations Honolulu Heart Program/Honolulu-Asia Aging Study, Physicians’ Office Tower, Kuakini Medical Center, Honolulu, Hawaii, United States of America, Department of Public Health, University of Hawaii at Manoa, Honolulu, Hawaii
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Helen Petrovitch,

Affiliations Honolulu Heart Program/Honolulu-Asia Aging Study, Physicians’ Office Tower, Kuakini Medical Center, Honolulu, Hawaii, United States of America, Pacific Health Research and Education Institute of the Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii, Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America
⨯
Webster Ross,

Affiliations Honolulu Heart Program/Honolulu-Asia Aging Study, Physicians’ Office Tower, Kuakini Medical Center, Honolulu, Hawaii, United States of America, Pacific Health Research and Education Institute of the Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii, Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America
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Kamal H. Masaki,

Affiliations Honolulu Heart Program/Honolulu-Asia Aging Study, Physicians’ Office Tower, Kuakini Medical Center, Honolulu, Hawaii, United States of America, Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America
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Beatriz Rodriguez,

Affiliations Honolulu Heart Program/Honolulu-Asia Aging Study, Physicians’ Office Tower, Kuakini Medical Center, Honolulu, Hawaii, United States of America, Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America, Department of Public Health, University of Hawaii at Manoa, Honolulu, Hawaii, Instituto Tecnologico de Monterrey, Monterrey, Mexico
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Randi Chen,

Affiliation Honolulu Heart Program/Honolulu-Asia Aging Study, Physicians’ Office Tower, Kuakini Medical Center, Honolulu, Hawaii, United States of America
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Timothy A. Donlon,

Affiliations Honolulu Heart Program/Honolulu-Asia Aging Study, Physicians’ Office Tower, Kuakini Medical Center, Honolulu, Hawaii, United States of America, Department of Research, Kuakini Medical Center, Honolulu, Hawaii, United States of America
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D. Craig Willcox,

Affiliations Honolulu Heart Program/Honolulu-Asia Aging Study, Physicians’ Office Tower, Kuakini Medical Center, Honolulu, Hawaii, United States of America, Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America, Department of Human Welfare, Okinawa University, Ginowan, Okinawa, Japan
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Bradley J. Willcox

Affiliations Honolulu Heart Program/Honolulu-Asia Aging Study, Physicians’ Office Tower, Kuakini Medical Center, Honolulu, Hawaii, United States of America, Pacific Health Research and Education Institute of the Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii, Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, United States of America, Department of Research, Kuakini Medical Center, Honolulu, Hawaii, United States of America
⨯

Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry

Qimei He,
Brian J. Morris,
John S. Grove,
Helen Petrovitch,
Webster Ross,
Kamal H. Masaki,
Beatriz Rodriguez,
Randi Chen,
Timothy A. Donlon,
D. Craig Willcox

Published: May 7, 2014
https://doi.org/10.1371/journal.pone.0094385

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Much evidence supports He, et al. findings

Posted by samarastt on 11 May 2014 at 03:49 GMT

There are a number study areas that support the findings in study by He, et al.

1. Within a species, the smaller individual tends to live longer
2. Smaller animals created through caloric restriction live longer
3. Centenarians are quite short
4. US data show shorter ethnic groups have lower age-adjusted mortality rates
5. Females live longer than males
6. Six top populations in life expectancy are relatively short
7. Survival studies show shorter men are more likely to reach 90 or 100 years
8. About 20 longevity studies show shorter people live longer

Many biological mechanisms support the greater longevity of shorter, lighter people.

No competing interests declared.

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Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry

Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry

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Much evidence supports He, et al. findings

Posted by samarastt on 11 May 2014 at 03:49 GMT