TAT-Protein Blockade during Ischemia/Reperfusion Reveals Critical Role for p85 PI3K-PTEN Interaction in Cardiomyocyte Injury

Xiangdong Zhu; Zuo-Hui Shao; Changqing Li; Jing Li; Qiang Zhong; Jonathan Learoyd; Angelo Meliton; Lucille Meliton; Alan R. Leff; Terry L. Vanden Hoek

doi:10.1371/journal.pone.0095622

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Open Access

Peer-reviewed

Research Article

TAT-Protein Blockade during Ischemia/Reperfusion Reveals Critical Role for p85 PI3K-PTEN Interaction in Cardiomyocyte Injury

Xiangdong Zhu,

Affiliation Program in Advanced Resuscitation Medicine, Center for Cardiovascular Research, and Department of Emergency Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America
⨯
Zuo-Hui Shao,

Affiliation Program in Advanced Resuscitation Medicine, Center for Cardiovascular Research, and Department of Emergency Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America
⨯
Changqing Li,

Affiliation Program in Advanced Resuscitation Medicine, Center for Cardiovascular Research, and Department of Emergency Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America
⨯
Jing Li,

Affiliation Program in Advanced Resuscitation Medicine, Center for Cardiovascular Research, and Department of Emergency Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America
⨯
Qiang Zhong,

Affiliation Program in Advanced Resuscitation Medicine, Center for Cardiovascular Research, and Department of Emergency Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America
⨯
Jonathan Learoyd,

Affiliation Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Angelo Meliton,

Affiliation Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Lucille Meliton,

Affiliation Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Alan R. Leff,

Affiliation Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Terry L. Vanden Hoek

* E-mail: tvh@uic.edu

Affiliation Program in Advanced Resuscitation Medicine, Center for Cardiovascular Research, and Department of Emergency Medicine, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, United States of America
⨯

TAT-Protein Blockade during Ischemia/Reperfusion Reveals Critical Role for p85 PI3K-PTEN Interaction in Cardiomyocyte Injury

Xiangdong Zhu,
Zuo-Hui Shao,
Changqing Li,
Jing Li,
Qiang Zhong,
Jonathan Learoyd,
Angelo Meliton,
Lucille Meliton,
Alan R. Leff,
Terry L. Vanden Hoek

Published: April 21, 2014
https://doi.org/10.1371/journal.pone.0095622

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correction for funding

Posted by Xiangdong on 23 Apr 2014 at 15:06 GMT

I have noticed that the funding agents are missing. This work was supported by the Chicago Biomedical Consortium with support from the Searle Funds at the Chicago Community Trust (to T. L. Vanden Hoek and A.R. Leff), and by a grant from GlaxoSmithKline Center of Excellence (to A. R. Leff).

No competing interests declared.

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TAT-Protein Blockade during Ischemia/Reperfusion Reveals Critical Role for p85 PI3K-PTEN Interaction in Cardiomyocyte Injury

TAT-Protein Blockade during Ischemia/Reperfusion Reveals Critical Role for p85 PI3K-PTEN Interaction in Cardiomyocyte Injury

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correction for funding

Posted by Xiangdong on 23 Apr 2014 at 15:06 GMT