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Research Article

Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial

  • Arash Hossein-nezhad,

    Affiliation: Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, United States of America

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  • Avrum Spira,

    Affiliation: Department of Medicine, Section of Computational Biomedicine, Boston University Medical Center, Boston, Massachusetts, United States of America

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  • Michael F. Holick mail

    mfholick@bu.edu

    Affiliation: Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, United States of America

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  • Published: March 20, 2013
  • DOI: 10.1371/journal.pone.0058725

Reader Comments (2)

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Another Great Vitamin D Study

Posted by gshm50 on 20 Mar 2014 at 15:35 GMT

This is the second very high-quality study on vitamin D that I've read on this site. I hope there will be many more! With all the correlations that have been reported in the media about what vitamin D seems to link to, it is becoming increasingly urgent in my opinion for researchers to begin nailing down just exactly what vitamin D does and how it does it. The broad responses in genes reported in this study is one of the most exciting developments I've seen yet, and I hope it can be confirmed with studies on larger numbers of people.

Competing interests declared: I am paid to write articles about vitamin D research and opinion at a site called vitamin D Explained, which is currently a non-commercial site dedicated to raising awareness about vitamin D and can be found at http://www.dexplained.com