Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

Eugenia Trushina; Emirhan Nemutlu; Song Zhang; Trace Christensen; Jon Camp; Janny Mesa; Ammar Siddiqui; Yasushi Tamura; Hiromi Sesaki; Thomas M. Wengenack; Petras P. Dzeja; Joseph F. Poduslo

doi:10.1371/journal.pone.0032737

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Peer-reviewed

Research Article

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

Eugenia Trushina ,

* E-mail: Trushina.eugenia@mayo.edu

Affiliation Department of Molecular Pharmacology and Experimental Therapeutics and Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Emirhan Nemutlu,

Affiliation Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Song Zhang,

Affiliation Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Trace Christensen,

Affiliation Electron Microscopy Core Facility, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Jon Camp,

Affiliation Biomedical Imaging Resource, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Janny Mesa,

Affiliation Department of Molecular Pharmacology and Experimental Therapeutics and Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Ammar Siddiqui,

Affiliation Department of Molecular Pharmacology and Experimental Therapeutics and Neurology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Yasushi Tamura,

Affiliation Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Hiromi Sesaki,

Affiliation Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Thomas M. Wengenack,

Affiliation Departments of Neurology and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Petras P. Dzeja,

Affiliation Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Joseph F. Poduslo

Affiliation Departments of Neurology and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

Eugenia Trushina,
Emirhan Nemutlu,
Song Zhang,
Trace Christensen,
Jon Camp,
Janny Mesa,
Ammar Siddiqui,
Yasushi Tamura,
Hiromi Sesaki,
Thomas M. Wengenack

Published: February 29, 2012
https://doi.org/10.1371/journal.pone.0032737

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 02 Mar 2012 at 22:53 GMT

The following article represents some of the media coverage that has occurred for this paper:

Publication: ABC 6 News
Title: “KAALtv.com - Mayo Clinic Alzheimer's Research”
http://kaaltv.com/article...

Publication: Daily Rx
Title: “Early Markers for Alzheimer's Disease | www.dailyrx.com”
http://www.dailyrx.com/ne...

Publication: Business Wire
Title: “Mitochondrial Dysfunction Present Early in Alzheimer's, Before Memory Loss | Business Wire”
http://www.businesswire.c...

Publication: Post Bulletin
Title: “Cell powerhouse might be at root of Alzheimer's - Post Bulletin”
http://www.postbulletin.c...

If you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article.

Competing interests declared: PLoS ONE Staff

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Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

Defects in Mitochondrial Dynamics and Metabolomic Signatures of Evolving Energetic Stress in Mouse Models of Familial Alzheimer's Disease

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Media Coverage of This Article

Posted by PLOS_ONE_Group on 02 Mar 2012 at 22:53 GMT